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Added a disclaimer on page 662. Many need to post better.
The pharma industry is not evil. It can be said that it's not perfect, as there have been successful lawsuits against drug producing companies. But the alternative of living without the pharma industry is a million times worse. Just because an industry has some problems doesn't mean it's a good idea to reject it altogether.
The covid-19 vaccines for example are a product of cooperation. The FDA and the vaccine-producing companies have been working together very closely (literally in the same buildings and rooms, looking over each other's shoulders), which minimizes any possibility of not just error but also of fraud. It's the same with the covid-19 treatments. This is a requirement given from the US government specifically for the purpose of guaranteeing safety.
I've honestly never seen anything else in my life that has been this rigorously tested under safety protocols of this level.
Meanwhile Ivermectin as a covid-19 treatment has not even been recommended by the manufacturer Merck, as people here have pointed out. Here's the statement:
"- No scientific basis for a potential therapeutic effect against COVID-19 from pre-clinical studies; - No meaningful evidence for clinical activity or clinical efficacy in patients with COVID-19 disease, and; - A concerning lack of safety data in the majority of studies."
On November 05 2021 23:07 Sermokala wrote: Its incredible what the difference between medicine that is tested for something and is proven good and medicine that is tested for something and not proven good in the eyes of scientists and the media.
The stupid crowd being so obsessed with made up conspiracies. Ivermectin just does not work on covid, it has been tested it sucks. Sorry you were tricked by the same people that think JFK ghost is coming back to fight the deep state but you were.
Like why is Merck (who makes ivermectin) not big evil big pharma? What makes them good big pharma? They have 48 billion in revenue. Pfizer he 42 Billion in revenue and like half the stock value. Their is not even a hint of logic to this stupidity.
And Merck have an approved covid treatment its called Molnupiravir, and it is getting authorized and used before Pfizers was. Its just Ivermectin was not because that is not what it does.
This crowd is basically mad that Antivan is not being prescribed for erectile disfunction without realizing that Viagra is and unlike Anitvan it actually helps with ED.
Ivermectin is a generic drug and anybody can make it. There's no profit in it. I can't believe people still bring up Merck as some argument.
Because Merck developed it and is still a major manufacturer of it? The same wait there is Generic Viagra and Pfizer is a major manufacturer of it......
And it is just stupidity at this point that it is talked about around covid, it does not work.
On Oct. 11 drug company Merck applied for emergency use authorization from the FDA for its COVID-19 pill called 'Molnupiravir;' it is not the same as Ivermectin.
They’re chemically different, meaning the structure of the molecules is not the same. According to the National Center for Biotechnology Information, a department within the National Institutes of Health's National Library of Medicine, the two have very different chemical structures. Ivermectin's formula is C48H74O14, while Molnupiravir's is C13H19N3O7 The organism they attack is different. Ivermectin attacks parasites. While the new Merck drug attacks RNA viruses. They attack each organism differently. Ivermectin ruptures the cell membrane, which paralyzes and kills the parasite. While Molnupiravir corrupts the mRNA inside the cell, preventing the virus from replicating effectively.. The drugs are used to treat two completely different conditions. Ivermectin treats conditions caused by certain parasites. It's approved orally to treat intestinal strongyloidiasis and onchocerciasis (also known as river blindness) and topically to treat head lice and rosacea. Molnupiravir, on the other hand, is being studied to treat COVID-19. Right now, there is no evidence that Ivermectin treats COVID-19.
vermectin has been pushed by right-wing politicians and activists promoting it as a supposed COVID treatment.[83][84][85] Misinformation about ivermectin's efficacy spread widely on social media, fueled by publications that have since been retracted,[86][87] misleading "meta-analysis" websites with substandard methods,[88][89] and conspiracy theories about efforts by governments and scientists to "suppress the evidence."[90][91]
In response to widespread misuse, the U.S. Food and Drug Administration, U.S. Centers for Disease Control, World Health Organization, American Medical Association, American Pharmacists Association, and American Society of Health-System Pharmacists issued statements in 2021 warning that ivermectin is not approved or authorized for the treatment or prevention of COVID-19, and advised against its use for that purpose outside of clinical trials.[60][22][92]
On September 1, 2021, health experts from the United States expressed concerns from reports of sharp increases in outpatient prescribing and dispensing of ivermectin with respect to levels before the pandemic.[93] These experts explain that the CDC has not authorized or approved ivermectin for the prevention or treatment of COVID-19. The American Association of Poison Control Centers has reported 1,440 cases of ivermectin poisoning through September 20, 2021, a three-fold increase compared to similar time periods in 2019 and 2020.[94]
On November 05 2021 23:05 ChristianS wrote: Not sure if you’re just trolling, but here’s PF-07321332 (Pfizer’s new drug, Paxlovid is just this plus ritonavir): Wikipedia And here’s Ivermectin: Wikipedia As you can see they’re totally different structures. So, yes, it’s unsurprising they perform differently in the clinic. Completely different drugs often do.
Ivermectin has been proven to be a protease inhibitor in a lab or so i've read. So it's the same mechanism of action.
Conclusion: they definitely don't work the same way. Although it's possible (although there is no evidence so far whatsoever that it even works at all) that Ivermectin combats Covid in a similar way, Ivermectin has multiple effects, some of which are potentially dangerous for humans, so even in the best case that Ivermectin does actually work to combat Covid (once again, no evidence so far), it may have worse side effects. The medicine Pfizer developed may also have side effects, but it is designed to specifically target a protease used in critical processes by the SARS-CoV-2 virus, and that hopefully limits unwanted and dangerous side effects.
I remember reading it in a different fact check article and it admitted some in vitro study showed it. I just don't remember the article exactly and i never looked for the study.
If you are talking about neurological side effects from ivermectin then you should know that ivermectin doesn't cross the blood brain barrier.
Also i love how your fact check article uses Pfizer spokeperson as a source, very thrustworthy!
As opposed to the Ivermectin is a miracle drug crowd who are both competent and completely trustworthy? I don’t understand why people are so wedded to it. Let’s even assume it has some effectiveness in this domain.
Why would it be more effective incidentally, being designed for a completely different clinical scenario than specific Covid treatments being developed?
Unless I’ve missed it I haven’t even seen the manufacturers themselves extol its virtues as a Covid treatment, although I believe it’s licensed for generic reproduction, that’s still a big prestige boost.
Merck the company that makes ivermectin has a drug in development that costs 19-25$ to produce for a regimen and they plan to charge 700$. How is that compared to a prestige boost?
The price of new medicines are not based on production cost, but no development cost not just for the drug it self, but also for drug they tried to devolpe but failed for some reason. Also the drug can only be sold for a short period of time until the virus ends or better drug as available. It like if you spend four years renovating 10 hours but nine collopsed, and you look at the price of the one house and only for the cost of the land and materials. Then say it's to expensive.
On November 05 2021 23:07 Sermokala wrote: Its incredible what the difference between medicine that is tested for something and is proven good and medicine that is tested for something and not proven good in the eyes of scientists and the media.
The stupid crowd being so obsessed with made up conspiracies. Ivermectin just does not work on covid, it has been tested it sucks. Sorry you were tricked by the same people that think JFK ghost is coming back to fight the deep state but you were.
Like why is Merck (who makes ivermectin) not big evil big pharma? What makes them good big pharma? They have 48 billion in revenue. Pfizer he 42 Billion in revenue and like half the stock value. Their is not even a hint of logic to this stupidity.
And Merck have an approved covid treatment its called Molnupiravir, and it is getting authorized and used before Pfizers was. Its just Ivermectin was not because that is not what it does.
This crowd is basically mad that Antivan is not being prescribed for erectile disfunction without realizing that Viagra is and unlike Anitvan it actually helps with ED.
Ivermectin is a generic drug and anybody can make it. There's no profit in it. I can't believe people still bring up Merck as some argument.
Because Merck developed it and is still a major manufacturer of it? The same wait there is Generic Viagra and Pfizer is a major manufacturer of it......
And it is just stupidity at this point that it is talked about around covid, it does not work.
On Oct. 11 drug company Merck applied for emergency use authorization from the FDA for its COVID-19 pill called 'Molnupiravir;' it is not the same as Ivermectin.
They’re chemically different, meaning the structure of the molecules is not the same. According to the National Center for Biotechnology Information, a department within the National Institutes of Health's National Library of Medicine, the two have very different chemical structures. Ivermectin's formula is C48H74O14, while Molnupiravir's is C13H19N3O7 The organism they attack is different. Ivermectin attacks parasites. While the new Merck drug attacks RNA viruses. They attack each organism differently. Ivermectin ruptures the cell membrane, which paralyzes and kills the parasite. While Molnupiravir corrupts the mRNA inside the cell, preventing the virus from replicating effectively.. The drugs are used to treat two completely different conditions. Ivermectin treats conditions caused by certain parasites. It's approved orally to treat intestinal strongyloidiasis and onchocerciasis (also known as river blindness) and topically to treat head lice and rosacea. Molnupiravir, on the other hand, is being studied to treat COVID-19. Right now, there is no evidence that Ivermectin treats COVID-19.
vermectin has been pushed by right-wing politicians and activists promoting it as a supposed COVID treatment.[83][84][85] Misinformation about ivermectin's efficacy spread widely on social media, fueled by publications that have since been retracted,[86][87] misleading "meta-analysis" websites with substandard methods,[88][89] and conspiracy theories about efforts by governments and scientists to "suppress the evidence."[90][91]
In response to widespread misuse, the U.S. Food and Drug Administration, U.S. Centers for Disease Control, World Health Organization, American Medical Association, American Pharmacists Association, and American Society of Health-System Pharmacists issued statements in 2021 warning that ivermectin is not approved or authorized for the treatment or prevention of COVID-19, and advised against its use for that purpose outside of clinical trials.[60][22][92]
On September 1, 2021, health experts from the United States expressed concerns from reports of sharp increases in outpatient prescribing and dispensing of ivermectin with respect to levels before the pandemic.[93] These experts explain that the CDC has not authorized or approved ivermectin for the prevention or treatment of COVID-19. The American Association of Poison Control Centers has reported 1,440 cases of ivermectin poisoning through September 20, 2021, a three-fold increase compared to similar time periods in 2019 and 2020.[94]
On November 05 2021 23:05 ChristianS wrote: Not sure if you’re just trolling, but here’s PF-07321332 (Pfizer’s new drug, Paxlovid is just this plus ritonavir): Wikipedia And here’s Ivermectin: Wikipedia As you can see they’re totally different structures. So, yes, it’s unsurprising they perform differently in the clinic. Completely different drugs often do.
Ivermectin has been proven to be a protease inhibitor in a lab or so i've read. So it's the same mechanism of action.
Conclusion: they definitely don't work the same way. Although it's possible (although there is no evidence so far whatsoever that it even works at all) that Ivermectin combats Covid in a similar way, Ivermectin has multiple effects, some of which are potentially dangerous for humans, so even in the best case that Ivermectin does actually work to combat Covid (once again, no evidence so far), it may have worse side effects. The medicine Pfizer developed may also have side effects, but it is designed to specifically target a protease used in critical processes by the SARS-CoV-2 virus, and that hopefully limits unwanted and dangerous side effects.
I remember reading it in a different fact check article and it admitted some in vitro study showed it. I just don't remember the article exactly and i never looked for the study.
If you are talking about neurological side effects from ivermectin then you should know that ivermectin doesn't cross the blood brain barrier.
Also i love how your fact check article uses Pfizer spokeperson as a source, very thrustworthy!
As opposed to the Ivermectin is a miracle drug crowd who are both competent and completely trustworthy? I don’t understand why people are so wedded to it. Let’s even assume it has some effectiveness in this domain.
Why would it be more effective incidentally, being designed for a completely different clinical scenario than specific Covid treatments being developed?
Unless I’ve missed it I haven’t even seen the manufacturers themselves extol its virtues as a Covid treatment, although I believe it’s licensed for generic reproduction, that’s still a big prestige boost.
Merck the company that makes ivermectin has a drug in development that costs 19-25$ to produce for a regimen and they plan to charge 700$. How is that compared to a prestige boost?
The price of new medicines are not based on production cost, but no development cost not just for the drug it self, but also for drug they tried to devolpe but failed for some reason. Also the drug can only be sold for a short period of time until the virus ends or better drug as available. It like if you spend four years renovating 10 hours but nine collopsed, and you look at the price of the one house and only for the cost of the land and materials. Then say it's to expensive.
Yes and no. The Pharma industry is not sacred, the most important for the price isn't development cost nor production but rather how much the market is willing to pay. In the US, this has gone terribly wrong, for example with Insulin.
Yes, development and research is expensive, but there are other sources of funding than sales. If left unchecked, the Pharma industry won't wait a second to blow billions on inflated salaries and marketing (including a shitton of free conventions for doctors prescribing their products).
Got my second vaccine dose yesterday (Pfizer this time; last time was J&J). Woke up maybe 10 times or so tonight but otherwise had no symptoms besides soreness at the injection site, so it went better this time (so far). Might have to do with me getting the jab in the late noon this time (last time in the morning hours)? I also lost 2kg since yesterday, which I did not expect because I've been eating a very significant calorie surplus over the past days. Very strange and not a welcome setback to my weight gain efforts lol
In Lithuania with 63% vaccination rate only 20% overall death reduction ourworldindata.org very weird. Unvaccinated still dying 9 times more as expected but deaths overall are almost the same.
On November 10 2021 18:52 Magic Powers wrote: Got my second vaccine dose yesterday (Pfizer this time; last time was J&J). Woke up maybe 10 times or so tonight but otherwise had no symptoms besides soreness at the injection site, so it went better this time (so far). Might have to do with me getting the jab in the late noon this time (last time in the morning hours)? I also lost 2kg since yesterday, which I did not expect because I've been eating a very significant calorie surplus over the past days. Very strange and not a welcome setback to my weight gain efforts lol
That weight loss would mostly be due to dehydration, though? I don't think it's possible to lose that much weight that quickly unless you lose a limb. :-P
On November 10 2021 18:52 Magic Powers wrote: Got my second vaccine dose yesterday (Pfizer this time; last time was J&J). Woke up maybe 10 times or so tonight but otherwise had no symptoms besides soreness at the injection site, so it went better this time (so far). Might have to do with me getting the jab in the late noon this time (last time in the morning hours)? I also lost 2kg since yesterday, which I did not expect because I've been eating a very significant calorie surplus over the past days. Very strange and not a welcome setback to my weight gain efforts lol
That weight loss would mostly be due to dehydration, though? I don't think it's possible to lose that much weight that quickly unless you lose a limb. :-P
Yeah, a good portion of it must've been water weight. But I only weighed 63kg before, so this is still... a bit of a mystery :o Maybe my body dehydrated faster than usual during sleep because of the response to the vaccine. That's a possibility.
Netherlands imposes lockdown measures as Covid cases hit new high
The Netherlands will become the first western European country to impose a partial lockdown since the summer, introducing strict new measures from Saturday in the face of record numbers of new Covid-19 infections.
The restrictions, announced by the caretaker prime minister, Mark Rutte, on Friday, will last at least three weeks and include the closure of bars, restaurants and essential shops from 8pm, with non-essential retail and services such as hairdressers to close at 6pm.
Gatherings at home would be limited to a maximum of four guests, all amateur and professional sporting events must be held behind closed doors, and home working was advised except in “absolutely unavoidable” circumstances, Rutte said.
"There are in fact two things, science and opinion; the former begets knowledge, the latter ignorance." Hippocrates, Law, 460-377 BCE
It has been almost two years since the pandemic. There are new cases of new patterns, new vaccines and new statistics on them, new side effects changing daily sometimes.
- There is not enough information for healthcare decisions.
- There is not enough time for statistics.
- New findings cannot instantly come to general vaccination.
But restrictions and new rules come so quickly.
Mandatory vaccination is for taking responsibility. I would say yes. But when it comes to the decision of losing a job or health what is the right choice? While there is no actual confirmation that a vaccine puts everyone around you to safety. Wearing masks and following all the restrictions are mandatory. Many people didn’t have the usual flu, any respiratory disease last year just because of wearing masks.
Unfortunately, we are left with opinions, restrictions and tolls.
On November 14 2021 00:01 Lariliss wrote: "There are in fact two things, science and opinion; the former begets knowledge, the latter ignorance." Hippocrates, Law, 460-377 BCE
It has been almost two years since the pandemic. There are new cases of new patterns, new vaccines and new statistics on them, new side effects changing daily sometimes.
- There is not enough information for healthcare decisions.
- There is not enough time for statistics.
- New findings cannot instantly come to general vaccination.
But restrictions and new rules come so quickly.
Mandatory vaccination is for taking responsibility. I would say yes. But when it comes to the decision of losing a job or health what is the right choice? While there is no actual confirmation that a vaccine puts everyone around you to safety. Wearing masks and following all the restrictions are mandatory. Many people didn’t have the usual flu, any respiratory disease last year just because of wearing masks.
Unfortunately, we are left with opinions, restrictions and tolls.
"Just because of wearing masks"? Come one, where did you get that idea from? Areas with almost no use of masks also had fewer diseases. There were a multitude of different measures in place absolutely everywhere, some very effective and some completely useless. Determining which measures had what impact is very complicated. When masks were obliged alone, I dare you to find a time and place where it had a significant statistical effect.
In a high population density nation apparently 82% of 12+ year olds being fully vaccinated is not enough to fully open.
The government has been waiting to long to respond to rising numbers that exceeded expectations (some rise was expected when you open up) and are still unwilling to put more pressure on the unvaccinated.
So now we're going back into some form of lockdown for 3 weeks (closing stores/bars/restaurants after dark) which is going to do fuck all because we're not buying time for anything. There is no 'buying time until people are vaccinated' because the vaccine is out and anyone who wants it can get it.
Hospitals are filling up again and we're nearing or have reached the situation we had during the first half of the year. The only bright spot is that deaths are still reasonably low.
Also here in Peru, in the province of Chincha of the Ica departmens, late last year and early this year authorities begun giving away Ivermectin for free, the result was that that province had the highest deaths per 100.000. Sorry, it just doesn't work.
Austria is starting a "lockdown for the unvaccinated", in effect tomorrow Monday for a duration of 10 days for all people who aren't vaccinated/recovered. Estimates say it would affect roughly 2 million people, that's 22% of the population. After the 10 days there'll be a re-evaluation. A vaccine mandate is not on the table.
The recent restrictions have led to a significant increase in vaccinations, so I think we can expect the coming measures to further increase the demand.
As much as I can understand Simmons' frustration, I'll say the "enemy" label will at best drive people further into their ideological trenches. When communication between people has been in decline, the best course of action is certainly not to put up more walls. I can't agree with him on this. Not because of his stance on vaccines, but because of his genius idea to resort to a very loaded term both generally and historically. The supposed "enemies" don't believe that they're in the wrong, if anything this label will only confirm them in their feeling that they've been on the run from what they consider an angry, hysterical mob. Both sides think that of the other side.
The thing that can unite people is a common understanding. Simmons needs to take a step back and calm himself, as hard as that may be. He should be wise enough to know better.
EPT
