My general criteria:
1) Is it FUN and do you WANT to?
2) Does it challenge you? (professionally and personally)
3) Have you thought about and prepared for the this-might-not-work-out scenario? Are you okay with that?
Best of luck and I really do hope to see you casting more. I enjoy your casts (despite being sidetracked with how off-point Rifkin gets) and hope it's something you enjoy & can keep working at!