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Scientists making attempt to Clone a Woolly Mammoth - Page…

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CatNzHat
Profile Blog Joined February 2011
United States1599 Posts
March 17 2012 19:49 GMT
#221
I want my own pet sabertooth squirell right MeOw!!!1!

but seriously this would be awesome, both in the sense of a scientific achievement, and also in awesomenessityx2.
ampson
Profile Blog Joined January 2011
United States2355 Posts
March 17 2012 19:56 GMT
#222
I want mammoth steak.
Goobus
Profile Joined May 2010
Hong Kong587 Posts
March 17 2012 19:59 GMT
#223
Some of you guys are saying how it's not a real mammoth - but it is! They're not cloning mammoth sperm and inseminating an elephant egg with it (I don't think that would work as elephants and woolly mammoths aren't close enough), they're creating an entire set of mammoth DNA and inserting it into an "empty" elephant egg cell.

For those of you who say it's not impressive, it really is - they have to repair the damaged parts of the DNA, which is really fragile and most likely in really bad condition due to its age. How they will repair the DNA is probably by replacing it with similar sequences in elephant DNA or such. It's a pretty big feat to clone an extinct mammal from thousands of years ago.
Goobus
Profile Joined May 2010
Hong Kong587 Posts
March 17 2012 20:09 GMT
#224
Some of you guys are saying how it's not a real mammoth - but it is! They're not cloning mammoth sperm and inseminating an elephant egg with it (I don't think that would work as elephants and woolly mammoths aren't close enough), they're creating an entire set of mammoth DNA and inserting it into an "empty" elephant egg cell.

For those of you who say it's not impressive, it really is - they have to repair the damaged parts of the DNA, which is really fragile and most likely in really bad condition due to its age. How they will repair the DNA is probably by replacing it with similar sequences in elephant DNA or such. It's a pretty big feat to clone an extinct mammal from thousands of years ago.
Otolia
Profile Blog Joined July 2011
France5805 Posts
March 17 2012 20:26 GMT
#225
On March 15 2012 22:14 Plexa wrote:
Screw ethics, I want to see mammoths in my lifetime

It's so fluffy I'm gonna die !

Source : YouTube
Rockztar
Profile Joined June 2011
Denmark210 Posts
March 17 2012 21:00 GMT
#226
*crosses fingers*
Please mess up and create an ultralisk, please mess up and create an ultralisk, please mess up and create an ultralisk...

Forikorder
Profile Joined August 2011
Canada8840 Posts
March 17 2012 21:12 GMT
#227
love the scientists of the current world is there nothing else they can be putting there brains into that they have to make wooly mammoths? the only reason to clone a wooly mammoth is for bragging rights
TheToaster
Profile Joined August 2011
United States280 Posts
March 17 2012 21:30 GMT
#228
For a while, I've stated that the field of biology needs to get it's priorities straight. First off, we don't even fully comprehend all the enigmas of human DNA, let alone a mammoth's. There are literally thousands of gene sequences that have unknown functions in terms of protein synthesis.

IMO, biology has always been a study revolving around the human body. Sure, there are tons of great things to learn about other species, but that knowledge should in turn help us advance our own biological functions. I'm talking medicine, cures for diseases, and all that jazz. After that, THEN would be the time to start cloning up species that really have no point to being alive.

In my eyes they are cloning a mammoth for the sake of cloning a mammoth, which is pointless. If someone could explain otherwise, please do. Personally I love physics. Consider this analogy, cloning a mammoth would be like a physicist perfecting the potato launcher instead of working on fundamentals like the Standard Model.
Oh, get a job? Just get a job? Why don't I strap on my job helmet, squeeze down into a job cannon, and fire off into job land, where jobs grow on jobbies!
JiYan
Profile Blog Joined February 2009
United States3668 Posts
March 17 2012 21:31 GMT
#229
quick question: what will they do with it if they are successful?
Forikorder
Profile Joined August 2011
Canada8840 Posts
March 17 2012 21:32 GMT
#230
On March 18 2012 06:31 JiYan wrote:
quick question: what will they do with it if they are successful?

pack it up in a zoo and tour around the world with a sign hanging around its neck

"give me money"
Aelip
Profile Joined November 2010
Denmark321 Posts
March 17 2012 21:35 GMT
#231
On March 18 2012 06:30 TheToaster wrote:
For a while, I've stated that the field of biology needs to get it's priorities straight. First off, we don't even fully comprehend all the enigmas of human DNA, let alone a mammoth's. There are literally thousands of gene sequences that have unknown functions in terms of protein synthesis.

IMO, biology has always been a study revolving around the human body. Sure, there are tons of great things to learn about other species, but that knowledge should in turn help us advance our own biological functions. I'm talking medicine, cures for diseases, and all that jazz. After that, THEN would be the time to start cloning up species that really have no point to being alive.

In my eyes they are cloning a mammoth for the sake of cloning a mammoth, which is pointless. If someone could explain otherwise, please do. Personally I love physics. Consider this analogy, cloning a mammoth would be like a physicist perfecting the potato launcher instead of working on fundamentals like the Standard Model.


I'm sorry, but science doesn't have to be about improving our lives alone. Science is gaining new knowledge, and cloning a mammoth would be a huge feat in both finding out what we're capable of and finding out more about the species.
Count9
Profile Blog Joined May 2009
China10928 Posts
March 17 2012 21:37 GMT
#232
On March 18 2012 06:32 Forikorder wrote:
Show nested quote +
On March 18 2012 06:31 JiYan wrote:
quick question: what will they do with it if they are successful?

pack it up in a zoo and tour around the world with a sign hanging around its neck

"give me money"

To fund the sabertooth tiger project, ofc.
-_-Quails
Profile Joined February 2011
Australia796 Posts
March 18 2012 01:21 GMT
#233
On March 18 2012 04:16 askTeivospy wrote:
Show nested quote +
On March 18 2012 00:00 -_-Quails wrote:
On March 17 2012 13:24 CursOr wrote:
There is no way to replicate all the DNA 100% accurate. I really don't give a shit what they are thinking.

Those things are going to be missing genes, have mutations, and crazy health problems even if they come out "living". I think this is a very bad idea.

You know the part in Jurassic Park where they used frog DNA to patch some of the gaps in the dinosaur DNA? In the movie that was done solely so they could have gender-changing raptors, but in real-life if you know approximately what genes you expect to be in a region and have access to DNA from a species similar enough in a relevant way in that region you can fill in the holes fairly well.

DNA isn't just a giant unknown code. Enough DNA is shared between species that, with modern elephants still existing we probably have enough available data to avoid the obvious pitfalls. There is of course a risk of some anomalous error existing in the mammoth, or being introduced through interplay between mammoth and elephant genes, or an error at a boundary between original and filler DNA.


You know that if you have a decent enough understanding of what a particular gene does you can often insert it without harm into very distantly related species. Examples include fish genes in plants, firefly genes in puppies, and jellyfish genes in pigs. Given this precedent, it is not impossible that, with sufficient modelling, mammoth DNA could be rendered usable and mammoths born with no significant health problems stemming from damaged source DNA or ill-chosen repair work.


Do you have any background in genetics or do you watch movies and listen to the grapevine to get your information? There are other aspects to getting a viable animal than just the genes, which you can't just replace with random animal genes and expect everything to go well. also lol at the phrase "sufficient modelling"

My post was refuting the idea that it would be impossible to create healthy mammoths starting with damaged DNA. I used the Jurassic Park frog-raptor as an accessible example, though in reality you would never use frogs to fix creatures much more closely related to birds and even with the closest living relatives there are likely to be too many holes and differences to actually make raptors. The examples I gave of inserting genes from random species without harm are ones that are easily found in the press, therefore the average TL reader can find non-paywall articles written for laypeople about them.

Would you have preferred an in-depth post explaining each choice of example, each example in depth, and how each compares to the mammoth task in hand? Or one that delves into the technical detail of what can currently be done, how, and what would need to be done in this project to maximise the chances of success.
I believe that the only obvious problem I failed to mention is the accelerated aging and arthritis suffered by some clones. I did not intend to suggest that random animals could or should be used for major repair work, but that modelling could be used to find places where elephant DNA can fill in the blanks well enough and that using genes from distantly related species is not necessarily deleterious.

Sufficient modelling is a cop-out because sufficient is undefined, but for me to define it with my current state of knowledge of this project would make me a liar. My sources of knowledge are a couple of courses of genetics, a semester long course on bioinformatics, and journal articles which I guess constitute a grapevine of sorts. This is an area of interest for me rather than a primary focus.
"I post only when my brain works." - Reaper9
Golgotha
Profile Blog Joined January 2011
Korea (South)8418 Posts
March 18 2012 01:22 GMT
#234
On March 18 2012 06:31 JiYan wrote:
quick question: what will they do with it if they are successful?


try to breed it.
Blasterion
Profile Blog Joined October 2010
China10272 Posts
March 18 2012 03:15 GMT
#235
On March 18 2012 10:22 Golgotha wrote:
Show nested quote +
On March 18 2012 06:31 JiYan wrote:
quick question: what will they do with it if they are successful?


try to breed it.

Ice Age Park, Mammoth Steak, New medicine discoveries, Bigger Zoo, the options are endless.
[TLNY]Mahjong Club Thread
Benjamin80
Profile Joined February 2012
581 Posts
March 18 2012 03:19 GMT
#236
If they can do this to a mammoth woulnt it be possible to do it with dinosaurs also like in Jurassic park?
[QUOTE][B]On March 19 2012 02:32 iNcontroL wrote:[/B] IF LIFE GIVES YOU LEMONS YOU CANNON RUSH[/QUOTE]
FrodoAndTheSlobStix
Profile Joined September 2011
United States158 Posts
March 18 2012 03:23 GMT
#237
I dont have much time so I didnt check if any one mentioned this. When I was in 5th grade they were talking about this. That was like 10 years ago. I dono I'd like to seeit.
You eat meat? Then your evil. Simple as that.
Mohdoo
Profile Joined August 2007
United States15723 Posts
March 18 2012 03:56 GMT
#238
On March 18 2012 12:19 Benjamin80 wrote:
If they can do this to a mammoth woulnt it be possible to do it with dinosaurs also like in Jurassic park?


If they had samples in tact enough, I'd assume so.
TehPrime
Profile Joined February 2012
United States180 Posts
March 20 2012 04:11 GMT
#239
On March 18 2012 12:56 Mohdoo wrote:
Show nested quote +
On March 18 2012 12:19 Benjamin80 wrote:
If they can do this to a mammoth woulnt it be possible to do it with dinosaurs also like in Jurassic park?


If they had samples in tact enough, I'd assume so.

Which it means it will most likely never happen until we find an intact bone marrows of dinosaurs.
OniGami
Profile Joined December 2011
Japan140 Posts
March 20 2012 04:17 GMT
#240
Can't wait for the dinosaur park!
物の哀れ
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