EPTOpioids and the immune system
Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells
However I've only read the abstracts so I can't say if the papers are any good.
Ask and answer stupid questions here! - Page 531
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Uldridge
Belgium5195 Posts
Opioids and the immune system Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells However I've only read the abstracts so I can't say if the papers are any good. | ||
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GreenHorizons
United States24156 Posts
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icystorage
Jollibee19350 Posts
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opisska
Poland8852 Posts
On November 21 2016 08:11 Cascade wrote: Why should not take painkillers like ibuprofen when you got a cold for example? It won't cure it, but it'll help you stuff done while you have it. And I don't quite see how "biting the bullet" makes me better off in the long run, when I can take painkillers. Are you saying there are long term side effects? Some side effects have been mentioned, but there is also the simple thing that you will probably heal faster if you don't reduce your fever, because fever helps with the immune response. Also, getting stuff done is exactly what you should not do - with a "cold" it's not that important, but proper flu is actually dangerous and you can end up with shit like heart damage if you stretch yourself too much during a flu. | ||
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Acrofales
Spain18392 Posts
On November 21 2016 15:52 opisska wrote: Some side effects have been mentioned, but there is also the simple thing that you will probably heal faster if you don't reduce your fever, because fever helps with the immune response. Also, getting stuff done is exactly what you should not do - with a "cold" it's not that important, but proper flu is actually dangerous and you can end up with shit like heart damage if you stretch yourself too much during a flu. Taking Ibuprofen to reduce fever is silly, unless you have an important thing to do, and can crash afterwards, in which case, you can take medicine to prop you up. But Ibuprofen's main use for me is as a painkiller (headaches mainly) and anti-inflammatory (nasty insect bites/stings). It's good to know a little bit about how your body works so you can distinguish between something that seems unpleasant, but is healing you and something that is just a nasty symptom that you can medicate away. Swelling of insect bites is not particularly useful(will stop pathogens that the insect might transmit, but most of the time is just an overreaction of your immune system). Same for a lot of pain: your body telling you there's something wrong. Once you have the message, take a pain killer, and of course treat the underlying cause (drink water and rest for headaches, see the dentist for toothaches, etc.) | ||
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opisska
Poland8852 Posts
On November 21 2016 18:23 Acrofales wrote: Taking Ibuprofen to reduce fever is silly, unless you have an important thing to do, and can crash afterwards, in which case, you can take medicine to prop you up. But Ibuprofen's main use for me is as a painkiller (headaches mainly) and anti-inflammatory (nasty insect bites/stings). It's good to know a little bit about how your body works so you can distinguish between something that seems unpleasant, but is healing you and something that is just a nasty symptom that you can medicate away. Swelling of insect bites is not particularly useful(will stop pathogens that the insect might transmit, but most of the time is just an overreaction of your immune system). Same for a lot of pain: your body telling you there's something wrong. Once you have the message, take a pain killer, and of course treat the underlying cause (drink water and rest for headaches, see the dentist for toothaches, etc.) You find Ibuprofen actually useful against inflamation? As far as I know, studies found a measurable effect only in extreme doses, the normal 200/400 mg pills should affect only pain. | ||
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Ghostcom
Denmark4783 Posts
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Acrofales
Spain18392 Posts
On November 21 2016 18:45 opisska wrote: You find Ibuprofen actually useful against inflamation? As far as I know, studies found a measurable effect only in extreme doses, the normal 200/400 mg pills should affect only pain. I don't know whether it actually works. I am just doing what the pharmacist recommended a while ago. A quick google turns up tons of pages claiming ibuprofen works against insect bites (swelling and pain). Moreover, it's technically an NSAID, not a painkiller: why is it classified primarily as an anti-inflammatory if it doesn't actually work as that? The NHS says ibuprofen should be used for: http://www.nhs.uk/Conditions/Painkillers-ibuprofen/Pages/Introduction.aspx So indeed, nothing about swelling from insect bites there (for which they recommend anti-histamine, which is my primary go-to for most insect bites, I just add Ibuprofen if they are particularly nasty). But I'm not a doctor, and have not actually gone through medical research to figure this out. | ||
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Ghostcom
Denmark4783 Posts
The mechanism of action is by inhibiting COX-II and thus the conversion of arachidonic acid into prostaglandines. Prostaglandines in turn trigger both inflammation as well as signal pain. Thus at "low dosage" the effect is primarily pain-quelling but there will obviously be a small (however likely clinically meaningless) anti-inflammatory effect. Mind you: The max intake of ibuprofen per day is 3200 mg/day EDIT: The above is obviously a simplification. | ||
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Thouhastmail
Korea (North)876 Posts
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Zambrah
United States7393 Posts
On November 21 2016 21:21 Thouhastmail wrote: I just found out that Clark Kent is the alter ego of Superman. Do you think he's going to kill me? He'll probably brood around a bit before doing it, but yeah he might. | ||
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Salteador Neo
Andorra5591 Posts
On November 21 2016 21:25 Zambrah wrote: He'll probably brood around a bit before doing it, but yeah he might. Unless your mom's name happens to be Martha ofc. | ||
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JimmiC
Canada22817 Posts
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Acrofales
Spain18392 Posts
. . . Damn it. | ||
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Thieving Magpie
United States6752 Posts
On November 21 2016 21:21 Thouhastmail wrote: I just found out that Clark Kent is the alter ego of Superman. Do you think he's going to kill me? Ever notice that superman BOTH says he never kills anyone AND has the technology to make lifelike androids who could probably take over a person's life if that person were to disappear. maybe I'm reading too much Nick fury? | ||
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greenelve
Germany1392 Posts
I hope you know which picture i mean and could link it. I dont know...how do i find this? edit: The third last one with 10.000 posts or something was saying you need a specifig postnumber to celebrate and the second last user with 20.000 or 30.000 was just saying "noobs". and everyone had a round number as they commented to the conversation, like 100, 500, 100, 5.000 and so on. | ||
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Emnjay808
United States10665 Posts
This is the ONLY time Ive ever wanted to take a day off (or even cut the day short) just so I can spend time with loved ones. I have an extremely good relationship with all my supervisors but I also want to approach this in the most professional manner when I ask about adjusting my schedule. And I also need to not disclose any information about my cousin's family because its extremely sensitive. Any ideas fam? Sorry about horribly structured sentences, its hard to talk about this so Im just typing as I go. | ||
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DarkPlasmaBall
United States46243 Posts
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Emnjay808
United States10665 Posts
On November 23 2016 14:17 DarkPlasmaBall wrote: First, talk to your cousin, and tell her that you need to talk to your boss about the situation. Decide on what/ how to tell your boss with your cousin's guidance. Then do it! Its complicated to explain, but things between my cousin and I are awkward right now. We dont speak much anymore ever since this whole thing unfolded. I just need a general idea how to explain that I need to take time off. | ||
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Cascade
Australia5405 Posts
On November 23 2016 14:02 Emnjay808 wrote: I have an extremely close relative who doesnt have a lot of time left (all ill ever elaborate, so dont ask). I just found out that their family is going to spend Thanksgiving with us. The problem is that I have a mandatory schedule with work (I work retail (thursday/blackfriday is the busiest days of the year) and I dont know how to explain to my superiors that I need to take time off. Also important to mention that my cousin works at the same place and that its her immediate family member that is the concerning person. Long story short: she hasnt disclosed any information about her family yet so that means Im not at liberty use that as a specific reason to take Thanksgiving off as well. This is the ONLY time Ive ever wanted to take a day off (or even cut the day short) just so I can spend time with loved ones. I have an extremely good relationship with all my supervisors but I also want to approach this in the most professional manner when I ask about adjusting my schedule. And I also need to not disclose any information about my cousin's family because its extremely sensitive. Any ideas fam? Sorry about horribly structured sentences, its hard to talk about this so Im just typing as I go. I think you can do this by just being vague. Tell your supervisor that it is personal reasons, and that it's really important for you. Tell them that you prefer to not talk about it. If you have a good relationship as you say, and you don't have a history of these mystery requests they will probably be fine with that. Offer to taker on other unwanted time slots in the future. If they insist on details you can say that it is someone close that is ill. You don't need to say that it's a relative. | ||
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