I've noticed that always after using computer my mouse hand's biggest thing on palm (don't know its name^^) gets little red and little akward, but not really painful. I have had this small problem quite long time and its little annoying though it doesn't really harm my gameplay. My keyboard hand gets little red too, but I don't feel anything special on it. Don't suggest that it would be some sickness thing, because im already 100% certain it isnt.
I have hard wooden table and Qck mini mousepad.
Plz give some help! >.<