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Added a disclaimer on page 662. Many need to post better. |
On October 05 2021 17:06 Slydie wrote:One very curious thing is that the EU and others gave billions of Euro for vaccine research at a very early stage: https://ec.europa.eu/info/research-and-innovation/research-area/health-research-and-innovation/coronavirus-research-and-innovation/vaccines_enBut part of the deal for getting that money was not maximizing vaccine prices once they were out afaik, they are sold more or less for production cost. Market economy is not quite functional in this case, and we should all be very happy for it! It is very interesting to see how the different vaccine intervals can have different effects. Here in Spain, it was mostly given at the minimum interval, which is very fast and convenient, but might not give the best protection against symptomatic disease. Booster shots are also inevitably coming to Europe, starting with people with compromised immune systems: https://www.ema.europa.eu/en/news/comirnaty-spikevax-ema-recommendations-extra-doses-boostersI don't think anyone knows if "antibody levels" are the equivalent of protection, but as so many governing bodies use the metric, there should be something to it. Edit: what I mean is that you might be well protected against infection despite a low level of antibodies. yes, antibodies are not the be all, end all of protection. But I do believe its one of the easiest things to measure so its logical that especially politicians jump on it as an indication.
When we were talking about boosters earlier I came across this piece which goes a little into it theconversation.com and talks about the difference between preventing infection, where a booster shot appears to be effective, and preventing hospitalization where even after 6 months the vaccine itself without booster is still barely showing a decrease in effectiveness.
Antibodies are (part of) what your body uses to fight of an infection and their presence indicated you used them in the past, aka you were infected or got vaccinated, but even if all your anti-bodies are gone your not defenceless, your body still remembers its encounter with previous infections and when it detects a new infection it starts production of anti-bodies again.
So long as that memory is persistent long term I question the usefulness of booster shots outside of vulnerable people in comparison to helping the rest of the world reach base level vaccination.
Is it really useful to go hard on preventing infection levels (as opposed to hospitalization levels) if your likely to constantly be importing infections from across around the world?
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it's said that antibodies give you a head start in fighting the illness; it's about 2 to 5 days(guesstimated by physicians).
- when you get infected and have active antibodies you just kill the virus right there and then;
- when you get infected and don't have antibodies active but are immune, your body needs to first identify the virus, then negotiate the 'right' reaction to have(has to do with the degree of reaction, degree of sensitization, temperature fluctuations, inflammation, etcetcetc) and then produce antibodies(and other type of 'helper' cells); that's about 2-5 days.
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Research from Harvard suggests Merck is selling their new covid pill molnupiravir at a 35x markup.Analysis of unoptimised cost came out at $17.74 per course and the US government has ordered 1.7 million courses at $700.Great news for Merck shareholders.
https://scholar.harvard.edu/files/melissabarber/files/estimated_cost-based_generic_prices_for_molnupiravir_for_the_treatment_of_covid-19_infection.pdf
From these data, the weighted mean market price for molnupiravir active pharmaceutical ingredient (API) was US$2,162/kg.
We assumed a treatment regimen of four 200 mg molnupiravir capsules twice daily for 5 days.
Using the weighted mean market price for molnupiravir with the costing algorithm described in the methodology, we estimate that the cost of production for molnupiravir capsules is US$1.74 per unit, or US$17.74 per 5-day regimen.
The US government has already ordered 1.7 million treatment courses, at about $700/patient.7 This price is equal to about 35 times the estimated sustainable generic price using current market prices for the active ingredient (API) observed in our analysis. Assuming optimization of molnupiravir synthesis, and a resulting drop in API cost, the US price would be equal to about 161 times the estimated sustainable generic price.
these types of stories prove just how cautious everyone is being in regards to vaccine safety.
Yes and it’s also a good thing that some governments are guiding certain ages to vaccines that are less dangerous to them.People of the same age groups in other countries would do well to heed the same advice.
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Moderna produces a much more intense immune response than Pfizer, so this isn't surprising. People who are having this issue would have had the same issue with actually getting covid though. I think for people who are healthy, Pfizer is the right call. It is an overall less intense vaccine.
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Thanks American conservatives, my 11 year old niece is going to have to be homeschooled because her heart rate now hits 160 walking to the bus stop. (This is 8 weeks after getting covid).
Real glad we let them spread misinformation on the basis of profits.
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On October 08 2021 02:12 Nevuk wrote:
Thanks American conservatives, my 11 year old niece is going to have to be homeschooled because her heart rate now hits 160 walking to the bus stop. (This is 8 weeks after getting covid).
Real glad we let them spread misinformation on the basis of profits.
I'm terribly sorry to hear about this. If I had children of school age who were unvaxed I'd never let them in schools. It is sad realizing how many other kids are in this situation and yet all we focus on is death. People like to treat it as a 0/1 situation, either you died or you're unscathed. This is a good example of that not being the case. Sigh. Very sad to hear. I really hope her situation is able to improve.
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Hello, they just gave me the astra vaccine but it did not react. I am afraid that it did not give me, is it bad that you do not have any symptoms?
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On October 08 2021 06:29 GabyLove wrote:
Hello, they just gave me the astra vaccine but it did not react. I am afraid that it did not give me, is it bad that you do not have any symptoms?
Many people don't experience noticable side effects. Chances are that the vaccine is effective on you, so there's no need to worry.
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On October 08 2021 02:12 Nevuk wrote:
Thanks American conservatives, my 11 year old niece is going to have to be homeschooled because her heart rate now hits 160 walking to the bus stop. (This is 8 weeks after getting covid).
Real glad we let them spread misinformation on the basis of profits.
Sorry man, and even sorrier for your niece. Slightly too young to be eligible for a vaccine and she'll be dealing with this for a long time. Hopefully scientists can come up with some therapies that help her regain lung function and fitness, because that's not at all uncommon in covid survivors.
BC's been using longer intervals between shots, 6-12 weeks for most of the population and a minimum of 4 weeks, and the data as of now shows that the vaccine is incredibly effective over the past month.
Based on last month’s data, compared with fully vaccinated individuals and after adjusting for age
differences, unvaccinated individuals are
• ≈ 11x more likely to become a case
• ≈ 58x more likely to be hospitalized
• ≈ 53x more likely to die
http://www.bccdc.ca/Health-Info-Site/Documents/COVID_sitrep/2021-10-01-Data_Summary.pdf
Summary article:
https://www.citynews1130.com/2021/10/07/unvaccinated-bc-death-rates/
It's fluctuating of course because the data sample size isn't gigantic, but it's pretty stark how big the difference is
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On October 08 2021 06:29 GabyLove wrote:
Hello, they just gave me the astra vaccine but it did not react. I am afraid that it did not give me, is it bad that you do not have any symptoms? Whether or not you have symptoms after getting the vaccine says nothing about the vaccine or its effectiveness on you. From what I understand it is simply a result of how aggressive your own immune system decides to react.
And since you say 'just', most side effects show up multiple hours later, generally the following day.
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On October 08 2021 02:12 Nevuk wrote:
Thanks American conservatives, my 11 year old niece is going to have to be homeschooled because her heart rate now hits 160 walking to the bus stop. (This is 8 weeks after getting covid).
Real glad we let them spread misinformation on the basis of profits.
You're Welcome.
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It's fair for people to seek more info on the causal relation between side effects (or lack thereof) with efficacy. To allow people to moderate their behaviour. Some of my friends who recently got the jab also had little or no side effect, and prefer to stay home as much as possible to avoid being higher risk carriers and infecting others. Not sure if they are overreacting. That's why clarity from health authorities would be nice.
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the virus does not avoid vaccinated people.
the vaccine doesn't create a shield around vaccinated people that prevents them from catching covid.
if someone infects you, vaccinated or not, the virus gets in you.
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EPT
