Coronavirus and You - Page 410

One preprint study*, published on the medRxiv server, found that 251 young people aged under 18 in England were admitted to intensive care with Covid-19 during the first year of the pandemic (until the end of February 2021).

Looking separately at PIMS-TS*, a rare inflammatory syndrome in children caused by Covid-19, the researchers found that 309 young people were admitted to intensive care with this condition – equating to an absolute risk of one in 38,911.

A linked preprint study**, also published on the medRxiv server and looking at data for England, concluded that 25 children and young people had died as a result of Covid-19, equating to an absolute risk of death from Covid-19 of one in 481,000, or approximately two in a million.

Dr Elizabeth Whittaker (Imperial College London) said: “It is reassuring that these findings reflect our clinical experience in hospital – we see very few seriously unwell children. Although this data covers up to February 2021, this hasn’t changed recently with the Delta variant. We hope this data will be reassuring for children and young people and their families.”

A third dose of the Pfizer/BioNTech Covid-19 vaccine can "strongly" boost protection against the Delta variant -- beyond the protection afforded by the standard two doses, suggests new data released by Pfizer on Wednesday.

On July 29 2021 00:41 Mohdoo wrote:
I would like to do yet ANOTHER victory lap:

https://www.cnn.com/2021/07/28/health/pfizer-third-dose-data-bn/index.html



Mohdoo was right again. Let me be clear with everyone: If you are an expert and your wife is also an expert, you are able to easily determine what public policy will be in a month and you can always tell what is true and what isn't.

Let me reiterate: It is totally possible for other people to see how things are going and what is going to happen, since we have a fundamental understanding of the science involved. I was telling people to get a 3rd shot a while ago.

Initial data shows booster dose of current vaccine (>6 mo. after 2nd dose of BNT162b2) has an overall consistent
tolerability profile while eliciting SARS-CoV-2 neutralization titers >5-8X for wild type and 15-21X for Beta variant the
range achieved after two primary doses
• Post dose 3 titers versus the Delta variant are >5-fold post dose 2 titers 18-55 y/o & >11-fold post dose 2 titers 65-85 y/o

On July 29 2021 01:05 Lmui wrote:


The pfizer document says this:



The 5 fold increase is realistically less than you'd expect in terms of real world effect. For 65+ the third dose is probably warranted, but titers is a poor way of measuring real world efficacy. If you can get one, it's worthwhile to get it, but not as key as the first two doses were.

The other thing to consider is that in countries where the doses were spread out, you got a ~3.5x increase (IIRC) anyways by waiting longer between doses (12 weeks instead of 3), so the marginal benefit is small for Canadians (outside of the elderly).

Looking through the document, I'm a bit more excited about the flu vaccine. If I could get my booster at the same time as the flu vaccine, and get good protection against all the major respiratory viruses at once I'd be quite happy.

https://s21.q4cdn.com/317678438/files/doc_financials/2021/q2/Q2-2021-Earnings-Charts-FINAL.pdf

The study methodology was previously described in the letter to the editor published in NEJM on April 15, 2021 concerning the variants first identified in the U.K. (Alpha, B.1.1.7) and the Republic of South Africa (Beta, B.1.351) using serum samples from eight participants obtained one week after participants’ second dose of the primary series in the Phase 1 clinical trial of the Moderna COVID-19 Vaccine. These most recent data include neutralization assays against additional variant strains. This additional analysis showed minimal impact on neutralizing titers against the Alpha and A.23.1 variants relative to those against the ancestral strain (D614G). This analysis also showed a modest reduction in neutralizing titers against the Delta (2.1-fold), Gamma (P.1, 3.2-fold), Kappa (3.3-3.4-fold), and Eta (4.2-fold) variants relative to those against the ancestral strain. Consistent with previous results, a 7.3 or 8.4-fold reduction in neutralizing titers was observed with the additional versions of the Beta variant relative to the ancestral strain. Additionally, an 8.0-fold reduction in neutralizing titers relative to the ancestral strain was observed with A.VOI.V2, the variant first identified in Angola, but currently not designated as a Variant of Concern or Interest.

On July 29 2021 05:09 Lmui wrote:
Going from 95% protective to high 80s (88%)? is due to a ~2.1x decrease in neutralizing titers. Getting a third dose for additional protection doesn't seem worthwhile to me in any country where a larger dose interval was observed for anyone besides the elderly and immunocompromised.

On July 28 2021 22:50 JimmiC wrote:

You do realize that your quotes both say in data up to feb 2021 which was before delta right? Saying it has not changed, when it has changed is silly.

What's your theory on why children are breaking records and adults are still a long says from doing so (though at these rates it might not be long in the worst hut states)?

On July 28 2021 17:25 iPlaY.NettleS wrote:
7 child patients admitted to ICU with 2,650 cases statewide.Is this because of the obesity rate in Alabama?

For context UK data from actual studies showed that the risk to children under 18 of being admitted to ICU was 1 in 38,911 with a death rate of around 2 per million.

https://www.bristol.ac.uk/news/2021/july/ncmd-covidrisks.html



Additionally Dr Whittaker of Imperial College London states that Delta variant has had no real impact on these figures



I'd suggest those numbers of 7 out of 2,650 child cases being in ICU either they are drastically undercounting the number of COVID cases in kids in Alabama or that kids in Alabama are more obese and unhealthy than UK kids.Likely a combination.

On July 30 2021 07:01 iPlaY.NettleS wrote:

Well it's not me saying delta hasn't changed things has it? It was Dr Whittaker of Imperial College, London.Trust the experts.

Children are at incredibly low risk of serious side effects from COVID and with the CDC now flip-flopping on vaccinated people not needing to wear masks inside because new research showing that vaccinated people still spread COVID and vaccinated people carry the same viral load as in unvaccinated people - https://www.dailymail.co.uk/health/article-9839697/Fauci-says-CDC-changed-mask-guidance-vaccinated-people-spread-Indian-Delta-variant.html - Dailymail but you just need to watch the 30 second clip of Fauci in the article stating that.So I'd say stop focusing purely on cases because even the vaxxed are causing new cases, vaxxed can be superspreaders.Possibly they'll issue a reversal of that policy when the inevitable boosters roll out?

On July 30 2021 09:14 JimmiC wrote:

Because 7 out of 311 is a lot more than 1 in 38911

And it's not only in Bama at least Florida, gerogia, Missouri are also breaking child records.

On top of that half of people who get hospitalized get long term consequences, serious ones.

https://scitechdaily.com/half-of-hospitalized-covid-19-patients-develop-a-complication/amp/







And Texas is getting almost as scary as Florida.

https://www.google.ca/amp/s/www.texastribune.org/2021/07/29/texas-covid-19-hospitals/amp/

On July 30 2021 19:39 BlueStar wrote:
You guys, do realize the vaccines are not free, right?
The state buys them but all the money is taken from your pockets one way or another...

If someone has more scientific links, I'd be happy to dig in. Please share.

These articles from the media were created out of the fingers of some journalists who are only there to get more clicks. It's just a read to fill your free time but can't get real intel out of it.