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General:
Q is a huge nuke that increases the damage that the target takes in addition to slowing. Use this to focus someone down and whenever possible continue to attack the person you nuked.

W is a heal with a move speed bonus. You can use this for longetivity or for chasing as 1 rank is sufficient for that most of the time.

E is a big part of your mid game and works amazingly well in combo with Q. It does a split of physical and magical damage thus forcing the enemy to get dual resistances to reduce the damage.

R is now on a short cooldown with a very short duration. A well timed ult can turn a gank around in a huge way or be used to bait a ton of damage.



Setup:
Runes - Mpen in marks, mp5 per level seals, ap per level glyph, flat HP quintessences.
Mastery - 9/21/0, same as my Morgana guide.
Summoner spells - Ghost / Ignite or Cleanse/ Ghost if the enemy team has a ton of powerful stuns.
Champion skills - > QEQW then R>Q>E>W

Items -
Start - Doran's ring, hp potion
first trip to base - basic boots, blasting wand or meki pendant, 2-3 health potions
2nd trip to base - Berserker Greaves (or if there is a lot of cc merc treads, but later), blasting wand or meki pendant (whichever you didn't already get), stinger if you can afford it

Eventually you'll want to finish a Guinsoo's rageblade then Nashor's Tooth. After those 4 items the game should be close to over but if it's not I suggest getting hextech gunblade started because you're probably facing some pretty tanky champions that you'll need the lifesteal to beat.

Strategy:
By picking all of these tanky masteries, hp quints, and doran's ring, you will start with a ton of hp (something around just shy of 800) at level 1 and make it very easy to hold your ground. If you're confident in the damage exchange throw a Q at the enemy and take a few whacks then back away. Once you hit level 2 you can do some serious hurt with a Q followed by E activation and just going to town on an enemy champion. Most solo-mids will take about 1/4 to 1/3 of their HP with Q and a single auto attack during E. Use this to your advantage and if your opponent gets too cocky throw ignite on him and win. So far I've tested this against ashe, katarina, pantheon, and ezreal with great success. The damage output of most low level champions is too low to beat the burst of kayle. Once you have the hp lead you can continue to dominate the lane by last hitting with ease. At level 6 if you still haven't killed them then you should be able to save up enough mana to tower dive with ease.

Generally I'd say try to get red and blue buffs whenever possible. With blue buff and nashor's tooth your spells are almost max CDR so E comes off CD nearly as its effect wears off.

Make good use of kiting with kayle's superior move speed with W and her slow. You should never get killed by most melee champions.

Use Kayle's ult to turn the tide of a battle by making an enemy waste as much damage as possible. You can also use it to surprise an opponent when theyre trying to 1v1 you in the mid game.

Try not to be a dick and ks people once you have your 4 main items. She doesn't gain much from additional gold.



Updates to the guide as of 8/14/10

I've had more sucess with AS marks and glyphs instead of Mpen and CDR respectively.
Rageblade's recent buff makes it a decent choice after Nashor's Tooth but the recent metagame of tank tank tank tank tank teams make bloodrazor a better choice usually.

I've also taken a liking to leveling my skills as follows:
E W E Q E R E W then R>E>Q>W
Using E more often gives better chances to last hit and farm faster and focuses less on trying to gib and zone them with Q