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Ghostcom
Profile Joined March 2010
Denmark4782 Posts
Last Edited: 2018-11-01 19:52:53
November 01 2018 17:47 GMT
#14221
It does harm if the test is poorly defined, of dubious clinical importance, the implications are unclear, and the treatment options are bordering on non-existing (faeces transplantation has a long way to go yet).

EDIT: A false positive can quite often be a lot more dangerous than a false negative. See the Cochrane review on breast cancer.
Uldridge
Profile Blog Joined January 2011
Belgium4786 Posts
November 01 2018 21:26 GMT
#14222
What do you generally prefer? High significance or high power? It's sort of sad that you need to have a tradeoff between the 2.
Taxes are for Terrans
Ghostcom
Profile Joined March 2010
Denmark4782 Posts
Last Edited: 2018-11-01 22:01:41
November 01 2018 22:00 GMT
#14223
Please define what you mean. Because if I am to interpret that question based in medical/epidemiological terms it makes little sense - so I suspect we have a language issue. When it comes to tests I am much more interested in sensitivity and specificity. Significance testing on its own is more or less obsolete in my opinion. Both Greenland and Rothman have written excellent articles on the subject.
Artisreal
Profile Joined June 2009
Germany9235 Posts
Last Edited: 2018-11-01 22:21:55
November 01 2018 22:20 GMT
#14224
On November 02 2018 06:26 Uldridge wrote:
What do you generally prefer? High significance or high power? It's sort of sad that you need to have a tradeoff between the 2.

Nvm, entirely misread the comment without taking into account the posts before it.
passive quaranstream fan
Uldridge
Profile Blog Joined January 2011
Belgium4786 Posts
November 01 2018 23:18 GMT
#14225
Well, if you lower your rate of type I errors, i.e. changing your significance level from 0.05 to 0.001 for example, you'll need extreme amounts of evidence (data) in order to show something is truly deviating from the null hypothesis. This also makes sure that your type II errors skyrocket, because you being so stringent will also cause you to miss all the relevancy.
I know there are formulas to find the sample size etc needed to keep your type II error low enough while you set your significance level suuuuuper low (or high, whatever, more stringent), but surely there should be some way to figure out what the best alpha and 1-beta levels are for a certain experimental setup and the data that is available. I mean, how do you know it's relevant when you can arbitrarily choose your stuff, right? Sometimes it all feels like tinkering until something seemingly relevant pops out.
I know I'm a statistics rookie though, so don't bother with replying if this is way too full of mistakes.
Taxes are for Terrans
DarkPlasmaBall
Profile Blog Joined March 2010
United States44359 Posts
November 01 2018 23:29 GMT
#14226
On November 02 2018 08:18 Uldridge wrote:
Well, if you lower your rate of type I errors, i.e. changing your significance level from 0.05 to 0.001 for example, you'll need extreme amounts of evidence (data) in order to show something is truly deviating from the null hypothesis. This also makes sure that your type II errors skyrocket, because you being so stringent will also cause you to miss all the relevancy.
I know there are formulas to find the sample size etc needed to keep your type II error low enough while you set your significance level suuuuuper low (or high, whatever, more stringent), but surely there should be some way to figure out what the best alpha and 1-beta levels are for a certain experimental setup and the data that is available. I mean, how do you know it's relevant when you can arbitrarily choose your stuff, right? Sometimes it all feels like tinkering until something seemingly relevant pops out.
I know I'm a statistics rookie though, so don't bother with replying if this is way too full of mistakes.


Yup, that's statistics (and the art behind a lot of scientific studies in general)

As Ghostcom noted, accepting more Type 1 errors vs. accepting more Type 2 errors is usually based on context. Sometimes, a false positive leads to a "better safe than sorry" approach, like how you're supposed to treat every gun like a loaded gun (even if it's not). In terms of a false positive vs. false negative for a disease, it might depend on how costly (financially, physically, etc.) an unnecessary treatment (medicine, chemotherapy) might be vs. not treating it at all. In general, a simple solution to a lot of these very serious ethical dilemmas is to just repeat tests a few times, as it's exponentially less likely to receive multiple Type errors in a row. A common example of this is when women use 2 or 3 different pregnancy sticks when testing whether or not they're pregnant.
"There is nothing more satisfying than looking at a crowd of people and helping them get what I love." ~Day[9] Daily #100
Uldridge
Profile Blog Joined January 2011
Belgium4786 Posts
November 01 2018 23:38 GMT
#14227
But doesn't that make statistic inherently flawed? I mean, it's been shown to be prone to abuse.
I mean, I understand why it's used and I understand the invaluable insight it might give us, but it still feels wrong, if you know what I mean. It's like knowing the raft you've made to escape the island is made out of crappy driftwood, which might make you drown at any point in time, but you're forced to use it any way if you want to chance it off the island.
I just wish there were hard boundaries instead of all this fuzzy stuff, but I guess that's our human limitation..
Taxes are for Terrans
Simberto
Profile Blog Joined July 2010
Germany11517 Posts
Last Edited: 2018-11-01 23:54:58
November 01 2018 23:52 GMT
#14228
No, why would it make statistics inherently flawed?

It only means that you get have different types of statements from statistics when compared to the logic of other parts of maths. In other parts of maths, you usually prove if something is true, or not, (or possibly if it is impossible to prove that it is true). And the same type of results are also true in the applications of that maths, any type of uncertainty is usually based in the uncertainty of the input data, not the uncertainty of the maths.

In statistics, you use the same type of logic and proofs for the maths itself, but in the applications, this leads to statements with a margin of error. That does not make the statements any less valuable, you just need to understand what the statement actually is, and that is a bit more complex. Because it is usually not "x is true" or "x is untrue", but "x has a 96% chance of being true and a 4% chance of being untrue". This statement itself is still mathematically 100% true, but the problem is that people don't understand that statement, and think it actually means "x is true".

The problem is not with statistics, but with people not understanding what statistics tells them.

As a clear example of that, take a look at the 2016 election in the US. There were predictions that Hillary Clinton had a 70% chance of winning. After Donald Trump won, people claimed that these prediction were wrong, because Clinton didn't win. The statement may have been wrong, but it was definitively not wrong for that reason. Because if Hillary Clinton had a 70% chance of winning, that means that she has a 30% chance of losing. Just because the percentage is higher than 50% does not mean that it is certain, and if it doesn't happen, the prediction was wrong.
Uldridge
Profile Blog Joined January 2011
Belgium4786 Posts
November 02 2018 00:01 GMT
#14229
No I understand all that, and I agree with you. It's like the justice system. In theory it should work, but it turns out that in practice is completely abusable and many guilty people get out free (because there's not enough evidence causing reasonable doubt. I understand you can't put the person in jail when there's not enough evidence, but he still committed the crime).

The fact that you can arbitrarily pick a significance level, or do some p-hacking to make your results look promising seems like an inherent flaw. We shouldn't be able to do that. There should be ways to circumvent that, by using some rigorous formulations on what you can and can't do.
For instance, why is 0.05 significance value so widely used in life sciences? Why not use 0.01? Why not use a custom significance value suited for your experimental set up, based on clearly defined ways to get to that custom significance value?
Taxes are for Terrans
Ghostcom
Profile Joined March 2010
Denmark4782 Posts
Last Edited: 2018-11-02 06:17:12
November 02 2018 05:21 GMT
#14230
P-values are on the way out in life sciences for many reasons, one of them being exactly what you point out. More importantly whether or not there is a statistical significant difference is actually (bordering on) meaningless. The important question is whether or not there is a clinical one. Thus effect size and confidence intervals (which should be interpreted as a question of how certain we are of the point-estimate and not as a pseudo-p-value) are what is considered lege artis to report.

In fact, all major journals have agreed to ban p-values from their papers (but they don't really do that in practice though).

This paper by Greenland et al is probably one of the more crucial ones in this regard: https://link.springer.com/article/10.1007/s10654-016-0149-3

bo1b
Profile Blog Joined August 2012
Australia12814 Posts
November 02 2018 08:17 GMT
#14231
When are German men going to step their game up, sexually?

https://www.yourtango.com/200938569/worlds-10-best-worst-lovers
_fool
Profile Joined February 2011
Netherlands678 Posts
November 02 2018 08:43 GMT
#14232
On November 02 2018 17:17 bo1b wrote:
When are German men going to step their game up, sexually?

https://www.yourtango.com/200938569/worlds-10-best-worst-lovers


The Germans (and the whole of Northern Europe, for that matter) are still waiting for an EU standard for this. Length of foreplay, satisfaction rates, etc. The whole climate thing has been taking top priority, though, so the topic has been moved to somewhere mid 2020's. A shame, really. We really could have made a mark here.

Of course, individual countries are free to implement their own preliminary standards, so not all is lost.
"News is to the mind what sugar is to the body"
Artisreal
Profile Joined June 2009
Germany9235 Posts
November 02 2018 10:00 GMT
#14233
On November 02 2018 17:43 _fool wrote:
Show nested quote +
On November 02 2018 17:17 bo1b wrote:
When are German men going to step their game up, sexually?

https://www.yourtango.com/200938569/worlds-10-best-worst-lovers


The Germans (and the whole of Northern Europe, for that matter) are still waiting for an EU standard for this. Length of foreplay, satisfaction rates, etc. The whole climate thing has been taking top priority, though, so the topic has been moved to somewhere mid 2020's. A shame, really. We really could have made a mark here.

Of course, individual countries are free to implement their own preliminary standards, so not all is lost.

Holly shit, this would make for a perfect guideline for incels to finally "get" women.
passive quaranstream fan
bo1b
Profile Blog Joined August 2012
Australia12814 Posts
Last Edited: 2018-11-02 12:12:25
November 02 2018 12:11 GMT
#14234
Instead of worrying about Incels, you should worry about Gercel's when this info leaks, step it up buddy.

On November 02 2018 17:43 _fool wrote:
Show nested quote +
On November 02 2018 17:17 bo1b wrote:
When are German men going to step their game up, sexually?

https://www.yourtango.com/200938569/worlds-10-best-worst-lovers


The Germans (and the whole of Northern Europe, for that matter) are still waiting for an EU standard for this. Length of foreplay, satisfaction rates, etc. The whole climate thing has been taking top priority, though, so the topic has been moved to somewhere mid 2020's. A shame, really. We really could have made a mark here.

Of course, individual countries are free to implement their own preliminary standards, so not all is lost.


I'm just imagining a bureaucrat in Geneva putting an ISO standard together for all of this now lmao.
DarkPlasmaBall
Profile Blog Joined March 2010
United States44359 Posts
November 02 2018 14:18 GMT
#14235
On November 02 2018 21:11 bo1b wrote:
Instead of worrying about Incels, you should worry about Gercel's when this info leaks, step it up buddy.

Show nested quote +
On November 02 2018 17:43 _fool wrote:
On November 02 2018 17:17 bo1b wrote:
When are German men going to step their game up, sexually?

https://www.yourtango.com/200938569/worlds-10-best-worst-lovers


The Germans (and the whole of Northern Europe, for that matter) are still waiting for an EU standard for this. Length of foreplay, satisfaction rates, etc. The whole climate thing has been taking top priority, though, so the topic has been moved to somewhere mid 2020's. A shame, really. We really could have made a mark here.

Of course, individual countries are free to implement their own preliminary standards, so not all is lost.


I'm just imagining a bureaucrat in Geneva putting an ISO standard together for all of this now lmao.


So instead of metrosexuals, we'll have metric-sexuals?
"There is nothing more satisfying than looking at a crowd of people and helping them get what I love." ~Day[9] Daily #100
JimmiC
Profile Blog Joined May 2011
Canada22817 Posts
November 02 2018 14:24 GMT
#14236
--- Nuked ---
Liquid`Drone
Profile Joined September 2002
Norway28672 Posts
Last Edited: 2018-11-02 16:15:41
November 02 2018 16:15 GMT
#14237
sex is far too individual to be quantifiable like that. I mean, there are certainly things that most people like or things that almost everybody dislikes, but the main 'scientific' tip would be something like; 'talk openly about what you like and desire, be willing to experiment (but you don't have to do things you really don't like), spend time and don't be in a rush (occasionally it's fine!), be clean, respect your partner, use your tongue'. It's good to know where the clitoris is and stuff like that, but you can't make a flowchart of where to touch at what time because it varies from person to person and some people have entirely irrational likes or dislikes.
Moderator
bo1b
Profile Blog Joined August 2012
Australia12814 Posts
November 02 2018 16:30 GMT
#14238
No wonder the Germans suck at it then
JimmiC
Profile Blog Joined May 2011
Canada22817 Posts
November 02 2018 17:41 GMT
#14239
--- Nuked ---
Gorsameth
Profile Joined April 2010
Netherlands21691 Posts
November 02 2018 17:48 GMT
#14240
Ideally you would teach something like that in school at an appropriate age, but teaching kids about 'sex' is still taboo in most places.
It ignores such insignificant forces as time, entropy, and death
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