My opinion is that lately you have to use really meta skills with good innate damage so you can invest in defenses to survive the one shots. If you use other skills you often don't have enough damage or survivality (this is specially a problem if you play melee). This was less extreme some years ago when you had more options in builds for finishing the ultra lategame content.
But I don't see any buff or change that interest me enough for ignoring the defense nerfs. Right now I'm kinda dissapointed (but I will play anyway). Let's see the league content and patch notes.