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On December 15 2010 08:35 Zim23 wrote:
The key is the total body irradiation/chemo. Basically they destroyed his entire immune system (where HIV lives) and restarted his immune system using someone else' stem cells. They chose someone practically immune to HIV, so now all the WBC's running through his body are immune to HIV. I think the last step isn't 100% necessary, any stem cells might have worked, but getting stem cells from someone with this mutation increases the likelihood of a cure.
I just finished reading the journal article. From what I understand, the new stem cells are completely immune to HIV-1. If simple chemo killed 100% of the cells, then the new stem cells wouldn't have done anything. As it is, HIV is always latent in cells, which means that they can "sleep" through chemo. However, it was the fact that the new T-cells with the CCR5 mutations can't be entered by HIV that cured him.
Pretty amazing stuff.
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Basically, now that we know this mutation exists and we can stop it, we just need to figure out how to replicate it and put it in a vaccine. And that's relatively easy.
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Don't know if this is 100% believable but still it's just the first case of a successful recovery under the patient's unusual criteria's . Even so this is why stem-cell research is so important, people who are against it need their head fixed. Almost a million people die every year from HIV/AIDS. Some African countries have 80% of the population HIV infected (Don't remember which) but even if there was a cure discovered unless it's dirt cheap and can be mass produced, the poor in Africa will never benefit from it...so I don't see any hope.
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On December 15 2010 08:45 luckySe7en wrote:
time to go bang some hookers. giggigiggity goo
User was temp banned for this post.
The herp still stays with you.
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so its basically hitting a massive cold-reset button, and then rebooting your system with a immunity program so that your OS now boots up with default immunity.
or
Its, play as zerg, open 14 hatch and complain on forum about imba terran infantry
transition into LOOSING YOUR WHOLE FUCKING BASE in the mid game
mind control a scv,
build a command center and change your race
abandon zerg
rebuild at a gold expo
make imba tanks
SIEGE AND WIN :D
it doesnt seem so much like a cure as a rebirth @_@
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I'd be more scared of graft vs host than HIV if i was that guy. He's extremely lucky to find someone that matches with him that has the resistance genes...
gene therapy isn't easy either. If it was we'd be cured of almost all genetic linked diseases.
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On December 15 2010 08:50 IkeScurvy wrote:
Basically, now that we know this mutation exists and we can stop it, we just need to figure out how to replicate it and put it in a vaccine. And that's relatively easy.
it certainly is not. You cant jsut flush out a virus with some antibiotica.
You need those immune white blood cells because only they can kill the infected cells and keep up the immune system against other diseases. Because noone dies because of HIV you die because your system cant defend against anything else anymore, getting you killed by a simple cold. The only cure would be a change in your own DNA. And I for sure dont know if that'd work.
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On December 15 2010 08:15 DarkPlasmaBall wrote:
It also uses stem cells, which means there's no way we're going to be curing HIV here in America anytime soon -.-' Religion-forbid we ever use proper science to cure these types of problems; the terrible thought is well-established that stem cell research is "Playing God".
This is absolutely amazing though. I'm in awe.
i agree, we americans really need to get our noses out of the "holy" book and into a "true" book
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On December 15 2010 08:11 brain_ wrote:
Crazy. I'm no expert, but did the timeline go like this?
1) Patient infected with HIV
2) HIV virus wipes out patient's white blood cells
3) Stem cells lacking the receptor protein are given to the patient
4) Stem cells differentiate into new white blood cells (lacking receptor protein)
5) Immune system repopulates with receptorless white blood cells that HIV is unable to attack
6) Working immune system. Existent HIV molecules die out because they cannot reproduce.
amirite?
that's probably it. Even so, that's pretty awesome we can produce that, and not just in our dreams anymore, lolol
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On December 15 2010 08:39 Firereaver wrote:
Zzzz! Please do NOT get your hopes up.
Unrelated allogeneic Stem Cell Transplants(SCT) is itself a very morbid and high mortality procedure costing well over 600,000 USD (Total treatment costs) and longterm immunosuppression. Over a period of 1-2 years , projected treatment for adult leuk's - costs are anywhere between 1-2 million USD especially if there is complication or relapse.
AML is a frequent complication of HIV in the first place and HIV-AML is poor prognosis to begin with. A normal Allogeneic SCT for Myeloproliferative disorders already puts you at anywhere between 10-40% mortality risk, varying on the place you get it done at, not to mention anything about the morbidity of the procedure.
Now regarding this particular treatment-theory, PLEASE REMEMBER(and this has to be in caps) YOU HAVE TO BE HLA-MATCHED with the donor to even think of a transplant option to begin with and the chances of that happening is in the 1/10-100million chance given the 2 Bone-marrow databases in the world currently i.e USA & Germany. On top of that, the CCR5 mutation is an EXTREMELY RARE one to begin with and the chances of finding a HLA match within this select population is literally IMPOSSIBLE!
Now if suppose a Haplo-matched individual with CCR5 mutation did come along, the chance of GVHD related death alone would make me discourage the patient from even consider this as a viable treatment option.
Also to keep things real, HIV is no more a 'killing' disease. As long as proper precautions are taken and antiretroviral support is continued, an affected persons 10 year survival is quite high and I have personally seen the first patient to be diagnosed as HIV-positive (in 1985-86) in India who still follows up at our hospital. He is quite fine and aside from having to wear socks and shoes and maintain a high level of personal hygiene he seems perfectly normal, all this - living in a third-world country and now almost 25 years into the disease process.
While the case is interesting, please read the Lancet reference about it likely not having any immediate impact on HIV-treatment. Also, steer clear of pseudo-scientific sensationalism and I'm not saying that to sound patronising in any way.
Cheers!
This^^ ... Just finishing up my research project for HIV primary prevention and secondary screening. Despite the CCR% mutation, HIV is known for having a remarkably high level of genetic drift meaning that a variant form could exist that would still be able to enter the lymphocytes with the CCR5 mutated receptor. It is likely that the patient still has virions in the bloodstream, but they are below detectable levels (which are currently 1500 viral copies/mL i believe). Of these, it is more than likely that one such virion will be able to circumvent the CCR5 mutation, enter lymphocytes and then either become latent or clonally expand. The result will be another onset of AIDS, albeit very very delayed.
The point is THIS IS NOT A CURE. It is a series of highly risky events that likely reduced viral load levels to below detection. It would never be reproduced in clinical trials or the like.
If HIV was that cut-and-dry the vaccination programs that have existed for nearly 10 years would have developed a working molecular vaccine by now. But the virus' intrinsic mutation rate makes this highly difficult.
Also, based on my graduate research in regenerative med, hematopoietic stem cell therapies have a very low success rate despite the media hype. Oh and these are NOT the same type of stem cells that critics oppose, those are embryonic. This common misconception is really holding back the regenerative medicine field.
Still, I am happy for the dude. I hope this helps clarify things...CIAO
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Its nice but I think one of the main things is that these gene mutations only protect against the early stage of the HIV virus. Im not entirely sure on the details through because the presentation I saw on these gene mutations that allow for HIV protection was a while ago.
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On December 15 2010 08:19 ZERG_RUSSIAN wrote:Show nested quote +On December 15 2010 08:15 DarkPlasmaBall wrote:
It also uses stem cells, which means there's no way we're going to be curing HIV here in America anytime soon -.-' Religion-forbid we ever use proper science to cure these types of problems; the terrible thought is well-established that stem cell research is "Playing God".
This is absolutely amazing though. I'm in awe. Different type of stem cell, from what I read. Not embryos, but stem cells that every adult has.
From my limited understanding and research on the subject adult stem cell transplants have been much more fruitful in research than embryonic stem cells for reasons such as mentioned in the article.
Unfortunately so many "modernists" have their nose so ingrained in their anti-religion fervor that they themselves are becoming the short-sighted and ignorant masses that they themselves accuse the religious of.
Of course most religious groups don't want to support, in their view, growing humans to harvest for cells-- but just because folks hate religion doesn't mean they need to wage a crusade against it while ignoring the topic at hand. Adult stem cells have cured people in the past, and in this case they made a ground breaking cure on HIV. This is amazing stuff, yet so many folks want to turn the hate on religion so quickly that it's baffling. Even in this thread, where the evidence and original article clearly explain what happened we still find folks hating on religion because in their view the religious won't allow this medical marvel to be studied in the US, which is obviously false for anyone who took the 30 seconds it took to read the full page.
Read, educate, then if you still want to -- lay the hate on. Don't lay the hate on first.
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The cure for HIV was there when it was created on purpose, good thing the cure is finally official to the media now...
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I love progress. And this is it. Even though it could be a smallest step forward.
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On December 15 2010 08:59 BeefyKnight wrote:Show nested quote +On December 15 2010 08:15 DarkPlasmaBall wrote:
It also uses stem cells, which means there's no way we're going to be curing HIV here in America anytime soon -.-' Religion-forbid we ever use proper science to cure these types of problems; the terrible thought is well-established that stem cell research is "Playing God".
This is absolutely amazing though. I'm in awe. i agree, we americans really need to get our noses out of the "holy" book and into a "true" book
Sigh,.... Please understand that Stem Cell therapy when they talk about it here is NOT the same as Embryonal Stem Cell therapy/research, which is currently illegal!
This is Haematopoietic Stem Cell research and to make it clearer, that is regarding Stem Cell rests that are present even in the adults, in this case within the Bone Marrow.
Stem Cell Therapy is currently widely practiced in the USA, and is hugely state-funded in terms of research grants etc.
Half-knowledge is SO irritating!!
Stem Cell Transplants have NOTHING to do with Embryonal Stem cells, as matters lie. Please don't go lampooning state policy when you know only half-truths on the matter.
Cord-blood transplants are NOT embryonal stem cells! Please people less blind-hate more knowledge! Dont become the very people you seem to despise in the first place i.e. "close-minded christians". + Show Spoiler +Also respect the Holy Book son. 
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Well i dont like the prospect of nuking youself. You need some insane macro to recover from that.
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all i can manage on this topic is.... wow
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This isn't really good news. It's just the media hyping something up.
People resistant to HIV have been known for at least about 10 years now.
Scientists haven't been able to convert that knowledge into anything tangible, and this guy being cured isn't something that they're going to put other people through either (obviously as bone marrow transplant is very risky).
Sensationalist story, but no real tangible improvements towards a cure.
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On December 15 2010 09:05 Trizz wrote:
The cure for HIV was there when it was created on purpose, good thing the cure is finally official to the media now...
how i love conspiricy theories..... this one is a good one
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EPT
