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Grad School: Biology PhD Part 1

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Zaranth
Profile Blog Joined June 2011
United States345 Posts
Last Edited: 2012-09-20 00:17:01
September 10 2012 01:56 GMT
#1

Grad School

Part 1


Introduction

Hello fellow TL netizens. I'm Zaranth, and I'm going to be sharing my graduate school know-how with you.

I'd like to note that this blog pertains mostly to those looking for a PhD in biology in the United States. I'm not sure how the processes work for the other science disciplines (chemistry, physics, etc), though I would think they are pretty similar. I have no idea what the process is like for liberal arts majors.

I'll be posting a series of blogs covering the different aspects of graduate school. Although this blog series will contain mostly my experiences, I'll also talk about some experiences of my fellow students. The series will consist of the following topics: Preparing for Grad School, Applying for Grad School, Interviewing for Grad School, Surviving Grad School, and After Grad School. I hope you enjoy, and I look forward to feedback and questions! Thanks!

Why go to grad school? The point of graduate school is accurately protrayed here: http://matt.might.net/articles/phd-school-in-pictures/

You're going to learn a lot about something very specific. You will expand knowledge, but no one else will understand what you are saying. In fact, you might spend five or six years doing research on a topic that only a handful of people really understand or care about. You'll belong to a select group of individuals. Once you've obtained those three letters after your name, there are a lot of options. The most popular ones include continuing on in academics or getting a job in industry. Staying in academics means you will have to do at least one post-doctorate stint (another 3-4 years) before you can think about applying for a faculty position at a university. Please consider this - if you're graduating college now, and you're 23, that means by the time you can get your first faculty position you'll be 32 or 33 years old. If you go into industry, you'll be placed in a higher position, probably like a manager, and get a better salary than you would without a PhD. There are many other avenues to follow after getting a PhD, but those are the main two. I want to point out that it is a very competitive market out there for PhDs. There is actually a glut of us graduating and looking for jobs, and there are not enough (this is not entirely due to the current state of the economy, by the way). Think about that when making your decision - how many years are you willing to put into this career choice, and how hard are you willing to work to get a job when it's all over?

What Grad School Is:
  • Hard work
  • High highs and low lows
  • Flexible (usually)
  • self-motivated


For some humorous looks at grad school life (we laugh because of the truth in each of these):
http://whatshouldwecallgradschool.tumblr.com/


http://electroncafe.wordpress.com/2011/05/04/scientific-process-rage/

What Grad School Isn't:
  • Easy
  • Impossible
  • Feeling successful on a daily/weekly basis
  • Mixing colored liquids together to make more colored liquids that create smoke (although it should be more like this ... much more fun that way)



Preparing for Grad School - what to do while still in undergrad



First, let me give you my background. I went to Purdue University in West Lafayette, IN, and got my B.S. in Genetics. While I was at Purdue, I worked in a lab for two summers and three academic years. I participated in the Women in Science program, but no other official organizations. I was in the marching band for my first semester but then I wised up and quit (just like Neil Armstrong). I was a member of the Purdue swing dance club after that, which was AWESOME. Gentlemen - if you are having a hard time meeting the ladies, JOIN A DANCE CLUB! Not only will you meet chicks, you'll also learn that you have hips, and if you stick with it you'll become swauve. Anyway, I came to the University of Massachusetts Medical School for grad school, and I'm now beginning my 6th year. My research focuses on the transcriptional regulation of the Cystic Fibrosis gene. I hope to graduate next year (2013).

Ok, now for the first question: What do I do as an undergraduate to prepare for graduate school?


Classes and Grades



As far as classes go, the majority of your courses should be biology courses (duh). However, I highly recommend taking at least one programming course. This was not a requirement for me, and I never took one, and now I regret that. A lot of biology data that is generated these days is high throughput, which means that you need a computer to help you analyze results. Even basic programming knowledge is extremely helpful. If you can swing it, learn at least one programming language as an undergrad, and have some understanding of writing programs. I would suggest learning a language like Perl, C++/C, Java/Javascript, Python, R, or Shell [e/n: Shell is a generic term encompassing a bunch of different scripting languages]. Once you know the syntax of one language, it's pretty easy to pick up another.

Get good grades. If you want to get accepted into graduate programs, you're going to need A's and B's in your biology courses, and A's and B's in your other science courses, such as chemistry and physics. I personally got C's in calc and physics, but I got A's and B's in everything else so my GPA was good (3.27/4.0). I also had semester honors twice. I think my GPA was on the low end of acceptable for graduate school, but they take other things into account as well.


Research / Experience



This should be a big part of your collegiate experience. As early as you can manage, try to get a position in a lab. If your school is a big research university, there should be plenty of opportunities. Talk to your guidance counselor and they should point you in the right direction. Alternatively, check out your school's website. All the professors and their research summaries should be present. Pick one or two that sound interesting, and send the professor an e-mail. Ask if they have room in their lab for you, explain why you want to work there, and be patient. If you don't get a response within a week, send them a polite reminder e-mail, including all the information from your first e-mail. Professors are super busy, and they are probably not ignoring you, they just forgot. If the reminder e-mail doesn't work, you could try to stop by their office and talk to them face to face, or contact another professor. Often you can coordinate this through your school's administrative office or your counselor.

During the summer, you should get an internship if possible. I was able to get funding through the Howard Hughes Medical Institution to continue my lab work throughout the summer for two summers in a row. The third summer, I was able to get an internship working at a company that made 3D movies of cellular processes.

Experience is key. I believe that my lab experience tipped the scales during my grad school application process. If I would have had less experience, I don't know that I would have gotten as many interviews … but more on that in the next blog! Here's a word of caution: During your experiences, think critically about how you feel when you're in the lab vs. not in the lab. Are you excited to go to the lab? Every day? Even after two years? Are you good with your hands? Are you producing results or just showing up? If you continue to be excited about lab work after a few years, and if you are producing good results, grad school looks good. If you whine and complain about going to lab, and you are doing only what it takes to get by, then grad school is not for you. Trust me.

Popular Question: Does it matter what research I do as an undergrad? Example: if I think I want to do cancer research as a career, should I only work in a lab that does cancer research?

Answer: Nope! It actually doesn't matter at all what kind of research you do as an undergraduate. The point is that you are actively doing it. I know a classmate who did research on potatoes. I did research on actin dynamics during corn fertilization. Now I do research on a human disease gene. Whatever you can do in undergrad, do it. The point is that you can hold a pipette and accurately measure stuff. Your grad school lab will teach you all the rest.

I thought that I wanted to do cancer research. When I started doing lab rotations, I discovered that I was really more interested in gene function and expression. Don't limit yourself - do what sounds cool!


Clubs / Extracurriculars



As I stated earlier, I was in the Women in Science club at Purdue. I didn't do any other biology-related clubs, or any other official organizations (fraternity, etc). A graduate school will look at these activities, but unless you were the president of the Biology Club or something like that, it doesn't matter that much. If you're passionate about a particular hobby, go be in that club. Do the best you can in the place you are the happiest. The graduate school wants to see that you are not a crazy person, that you have hobbies and enjoy them, and that's about it.

What if I've already graduated and have worked for a few years in a traditional job?

Many of my classmates did not come to graduate school immediately after undergrad. Instead, they got jobs elsewhere, in industry, for a few years before they decided on grad school. For some, this was financial, and for others, it was just their next career choice. Let me explain this a little. From what I understand, one can only progress so far in industry without a PhD. Therefore, to get a high-level position within a company, a PhD is pretty much required. Also, some people find out they hate what they are doing and want to change it up. Graduate schools don't discriminate - in fact, having that extra experience is actually a benefit. If you worked as a technician for a few years, chances are you have a good grasp of lab life and culture, and you know your way around the lab bench. Don't hesitate to apply to graduate school. You'll still have to go through the same application process as an undergraduate, though, and that will be covered in the next posting.


Books



I can recommend two general books about genetics that I have read. They are
"Genome" by Matt Ridley and "Abraham Lincoln's DNA" by Philip R. Reilly. These are not textbooks, but they cover some interesting and cool stories about genetics. Feel free to give them a read!



Part 2 of Grad Studies Biology is Here!

Brought to you by the TL Knowhow Team

Written by: Zaranth
Edited by: tofucake & MightyAtom
Maker of Cheerfuls @eZaranth
tofucake
Profile Blog Joined October 2009
Hyrule19188 Posts
Last Edited: 2012-09-10 01:55:29
September 09 2012 13:30 GMT
#2
^^
Liquipediaasante sana squash banana
MightyAtom
Profile Blog Joined June 2004
Korea (South)1897 Posts
September 10 2012 02:13 GMT
#3
I gotta say, I love the choice of the youtube videos, thanks for this!
Administrator-I am the universe- Morihei Ueshiba
Aerisky
Profile Blog Joined May 2012
United States12129 Posts
September 10 2012 03:29 GMT
#4
Sweet write-up!

Know-how is ever-growing I'm not into the hard sciences but this was still very interesting and informative, and I look forward to the next installments ^^
Jim while Johnny had had had had had had had; had had had had the better effect on the teacher.
Juliette
Profile Blog Joined September 2010
United States6003 Posts
September 10 2012 04:13 GMT
#5
Its great to see a knowhow relevant for me! Not sure if Biology is my choice (I'm looking into astrobiology...so double major in molecular/cellular bio + astronomy for my undergrad, so there's actual masters programs for it in a few different schools), but the knowledge is still extremely relevant

I will keep reading!
OKAY FROM THAT PERSPECTIVE I SEE WHAT YOU'RE TALKING ABOUT
Slaughter
Profile Blog Joined November 2003
United States20254 Posts
September 10 2012 06:18 GMT
#6
Fun read I just started my PhD this semester myself ^^
Never Knows Best.
shindigs
Profile Blog Joined May 2009
United States4795 Posts
September 10 2012 06:29 GMT
#7
Great write up, I was interested in doing a science PhD as well but decided against it after some consideration.

I would recommend most scientists to be to read Prize Fights (maybe you can add it to your list?):
http://www.amazon.com/Prize-Fight-Rivalry-Science-Macsci/dp/0230338909

It outlines sort of the politics and darker side of science that most of us are not familiar with. Stuff like professors taking credit for years of graduate student work, bitter rivalries, and human beings as human beings no matter their noble professions. One of the post-docs I worked with in undergrad emphasized finding a good and friendly group over a notable professor with a bad attitude.
Photographer@shindags || twitch.tv/shindigs
Slaughter
Profile Blog Joined November 2003
United States20254 Posts
September 10 2012 07:12 GMT
#8
On September 10 2012 15:29 shindigs wrote:
Great write up, I was interested in doing a science PhD as well but decided against it after some consideration.

I would recommend most scientists to be to read Prize Fights (maybe you can add it to your list?):
http://www.amazon.com/Prize-Fight-Rivalry-Science-Macsci/dp/0230338909

It outlines sort of the politics and darker side of science that most of us are not familiar with. Stuff like professors taking credit for years of graduate student work, bitter rivalries, and human beings as human beings no matter their noble professions. One of the post-docs I worked with in undergrad emphasized finding a good and friendly group over a notable professor with a bad attitude.


Yea people don't know but some of the drama that goes on in academic departments is on the level of reality TV....shit just got an idea for a show...
Never Knows Best.
DarkPlasmaBall
Profile Blog Joined March 2010
United States45210 Posts
September 10 2012 12:26 GMT
#9
This is an awesome write-up! Thanks for taking the time to flesh this all out

While a lot of this is geared towards biology in particular (as expected), I found a lot of it also applicable towards most other graduate studies, especially parts like "What Grad School Is" and "What do I do as an undergraduate to prepare for graduate school?" and "Experience is key."

Good stuff right here
"There is nothing more satisfying than looking at a crowd of people and helping them get what I love." ~Day[9] Daily #100
ghost_403
Profile Joined September 2010
United States1825 Posts
September 10 2012 12:31 GMT
#10
Great article ^^ Bit late for me, I just finished my Master's degree a few months ago, and just started PhD work.

One thing that I want to highlight for everyone is one of the points made above: PhD work is self-motivated. I can't stress that enough. As someone who is problem-solving driven, this aspect of grad school drives me mad. Your advisor will often provide very little direction, and still expect something out of you at some point. This is something you need to seriously consider before signing up for however many years of grad school you agree to.

And I'd love to hear Zaranth chime in on that. So far, that's been the most difficult part of grad school for me, and I'd appreciate some guidance on that.
They say great science is built on the shoulders of giants. Not here. At Aperture, we do all our science from scratch, no hand holding. Step aside, REAL SCIENCE coming through.
Zaranth
Profile Blog Joined June 2011
United States345 Posts
September 10 2012 14:34 GMT
#11
On September 10 2012 21:31 ghost_403 wrote:
Great article ^^ Bit late for me, I just finished my Master's degree a few months ago, and just started PhD work.

One thing that I want to highlight for everyone is one of the points made above: PhD work is self-motivated. I can't stress that enough. As someone who is problem-solving driven, this aspect of grad school drives me mad. Your advisor will often provide very little direction, and still expect something out of you at some point. This is something you need to seriously consider before signing up for however many years of grad school you agree to.

And I'd love to hear Zaranth chime in on that. So far, that's been the most difficult part of grad school for me, and I'd appreciate some guidance on that.


You're right, ghost. You have to have a good amount of self-motivation. I don't have a boss that comes in the lab to "check up" on us (in reality, making sure we are working the required amount). I count myself lucky in that regard, but I could easily decide to not show up in lab one day out of 5, and my professor wouldn't notice. I end up feeling a lot of guilt if I'm not in the lab working, so I don't give in to that temptation. Some people need a professor that checks in with them daily in order to keep motivated.

If you're feeling like it's hard to keep your motivation high, I would suggest a few things. One is setting weekly meetings with your professor, if possible. Another is to keep a daily calendar of what you want to accomplish. I have a white board with the days of the week on it, and I fill in the whole week Monday morning, so I know what I am doing on each day. I erase things as they are finished, so I also get a sense of accomplishment, even if the thing to finish was "cell culture." Experiments take a long time to complete, and it can feel like you're just going in circles. It can be helpful to take a step back from the mundane experiments and remind yourself of why you are in grad school, and what you hope to accomplish.

I hope that was helpful. If you'd like more ideas, maybe give us a few more details about your lab and project for more specific feedback. Good luck!
Maker of Cheerfuls @eZaranth
meegrean
Profile Joined May 2008
Thailand7699 Posts
September 10 2012 16:29 GMT
#12
lol, the youtube videos are informative.
Brood War loyalist
ZeaL.
Profile Blog Joined April 2009
United States5955 Posts
September 10 2012 19:34 GMT
#13
Its great that you're writing this up! I would have liked to have this resource like 5 years ago. If there is anything more important than anything in getting a PhD I would say it is choosing the right lab. Funding, tenured or tenure track(?), quality of lab mates (bitchy? cliqueish? nice?), management style of PI, etc. Deserves a full article imo.
Zaranth
Profile Blog Joined June 2011
United States345 Posts
September 10 2012 19:39 GMT
#14
On September 11 2012 04:34 ZeaL. wrote:
Its great that you're writing this up! I would have liked to have this resource like 5 years ago. If there is anything more important than anything in getting a PhD I would say it is choosing the right lab. Funding, tenured or tenure track(?), quality of lab mates (bitchy? cliqueish? nice?), management style of PI, etc. Deserves a full article imo.


It will come! Future articles include application process, interviews, surviving grad school, and possible careers after grad school. If there's anything you think should be highlighted, let me know and I'll be sure to include it.
Maker of Cheerfuls @eZaranth
Dknight
Profile Blog Joined April 2005
United States5223 Posts
Last Edited: 2012-09-10 21:19:11
September 10 2012 21:14 GMT
#15
On September 10 2012 16:12 Slaughter wrote:
Show nested quote +
On September 10 2012 15:29 shindigs wrote:
Great write up, I was interested in doing a science PhD as well but decided against it after some consideration.

I would recommend most scientists to be to read Prize Fights (maybe you can add it to your list?):
http://www.amazon.com/Prize-Fight-Rivalry-Science-Macsci/dp/0230338909

It outlines sort of the politics and darker side of science that most of us are not familiar with. Stuff like professors taking credit for years of graduate student work, bitter rivalries, and human beings as human beings no matter their noble professions. One of the post-docs I worked with in undergrad emphasized finding a good and friendly group over a notable professor with a bad attitude.


Yea people don't know but some of the drama that goes on in academic departments is on the level of reality TV....shit just got an idea for a show...


Eh. I think it's pretty obvious that there will be drama no matter where you go. To think otherwise is pretty naive. Nothing changes; not from high school, to university, to academia. If there is competition, there will be drama.


Also, hi from another UMass system doc student! You said you're sixth year so I'm guessing at this point you're an ABD?
WGT<3. Former CL/NW head admin.
Veldril
Profile Joined August 2010
Thailand1817 Posts
Last Edited: 2012-09-10 23:18:17
September 10 2012 22:20 GMT
#16
No mentioning on PHD comics? That's what make our grad life more tolerable!

I'm a Chemistry grad student in second years at Texas A&M and I really like your post. I am quite lucky as well that our boss is not pushing me everyday, only having progress report meeting once a week (that's what we call lucky in Organic Chemistry ) and literature meeting twice a month.

On September 10 2012 15:29 shindigs wrote:
Great write up, I was interested in doing a science PhD as well but decided against it after some consideration.

I would recommend most scientists to be to read Prize Fights (maybe you can add it to your list?):
http://www.amazon.com/Prize-Fight-Rivalry-Science-Macsci/dp/0230338909

It outlines sort of the politics and darker side of science that most of us are not familiar with. Stuff like professors taking credit for years of graduate student work, bitter rivalries, and human beings as human beings no matter their noble professions. One of the post-docs I worked with in undergrad emphasized finding a good and friendly group over a notable professor with a bad attitude.


Well, we kinda know that our work will be mostly in our professor name. You don't really see Nobel laureates accepting their prizes with their graduate students, do you We just think that getting a Ph.D and having a name in a good publication is more important. And if you really do the work and come up with the idea, you should get the credit as much as your professor (as long as you have proofs that you come up with the idea).

PS. Writing TL know how is kinda a great way for procrastination

EDIT: Oh one thing about programming. I think everyone who wants to go to grad school should learn the basics of Linux because most, if not all, supercomputers use Linux based system. Knowing how to use Linux shell will come in very handy. Also, get a Mac if you wants to go to a grad school and knows that at some point you need to do computational stuffs. Mac is UNIX based system, which Linux also is. So a Mac can pretty much do almost everything Linux can (but with less stability with a trade off of more GUI). Cygwin/CygwinX can do that for Windows, but it still a pain to use.
Without love, we can't see anything. Without love, the truth can't be seen. - Umineko no Naku Koro Ni
subV
Profile Joined June 2011
United States93 Posts
September 11 2012 01:58 GMT
#17
Nice article! I thought about grad school in biology before settling on med school (which is where I am now). But I was wondering: what drove you to choose a PhD program at a medical school? Are there any differences between programs at a med school vs. a regular university, aside from med schools doing primarily human disease-related research?
aRyuujin
Profile Blog Joined January 2011
United States5049 Posts
September 11 2012 05:41 GMT
#18
While I'm definitely not planning to go into science, I can definitely appreciate the massive amount of work and dedication one needs to get a phd in a field like that.

Glad to see the TL Knowhow field expanding , especially with more 'different' fields
can i get my estro logo back pls
opisska
Profile Blog Joined February 2011
Poland8852 Posts
September 11 2012 14:55 GMT
#19
What Grad School Is:

Hard work
High highs and low lows
Flexible (usually)
self-motivated


You should probably come to visit. If I am won't be enough for you, I will get you in touch with some grad students and show you the "hard work"

I am of the opinion, that the entire ideology of our society that you should "work hard", whatever that means, is bullshit. And it is particularly absurd in basic science - because honestly, it does not matter to anyone. It does not make people's lifes better if we publish an article, nobody dependes on that. So why should there even be any stress? I guess that it is made up by people who need to feel that they are doing something important to stay motivated. But they are seriously hurting my happy life with these ideas!

Honestly, the main reason why I am still a grad student is precisaly because it is NOT hard work. If I wanted to work hard, I could do so, at private sector, for 5x the money I am getting now. But I do not want that and thus I am quite happy with where I am. It is also a big part of the reason I choose science that is NOT in the lab - because lab people are usually under much more stress, because they have to work under time constraints on expensice equipement. My work, on the other hand, takes place on my computer, or somewhere in the fields of Argentina, if I am lucky sometimes.

In much the same way I find it absurd that some people think that we should go to "work" (meaning our offices) at set times of the day and sit there and work. Again, if I wanted such enviroment, I could be happily employed in a company. But considering that most of the time, it is really only my laptop I need to work, I work when and where I want - from home, from the park, whatever ... Luckily I work in an enviroment where nobody really wants me to to "sit out" the hours, but only to show some results once in a while. On the other hand, it actually requires a lot of cooperation from the management of the institution, because the local regulations (that are supposed to HELP the working class...) make that actually quite difficult to do legally.
"Jeez, that's far from ideal." - Serral, the king of mild trashtalk
TL+ Member
Zaranth
Profile Blog Joined June 2011
United States345 Posts
Last Edited: 2012-09-11 15:49:34
September 11 2012 15:48 GMT
#20
On September 11 2012 10:58 subV wrote:
Nice article! I thought about grad school in biology before settling on med school (which is where I am now). But I was wondering: what drove you to choose a PhD program at a medical school? Are there any differences between programs at a med school vs. a regular university, aside from med schools doing primarily human disease-related research?


hey subV! I chose my school based on the programs they offered and the opportunities for research. Honestly, I didn't really care that the program was a medical school. The school had money, young faculty, energetic grad students, and a great atmosphere. That's why I chose it. One thing to note is that there are no undergrads at the medical school, so there are limited changes for TAing experience. This can be good or bad - you are not required to TA classes, and then again you don't get the experience of teaching.

In my experience, there is a lot of basic science research that happens at medical schools. Yes, there is translational and clinical research, but there is definitely basic science research. One of the coolest research labs here studies the migratory patterns of Monarch butterflies. They take the butterflies and attach them gently to a stick. They fly but don't move forward. They can turn side to side. Then the researchers play with the magnetic field and sunlight angles to see how the butterfly responds. In this way they figured our how the butterflies migrate, and what they do when they can't see the sun. Check out http://reppertlab.org/ for more info.

I hope that addressed your questions.
Maker of Cheerfuls @eZaranth
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