The first entry:
The Last Express is a highly unique adventure game, set in real time (!). You play the role of an American doctor, pre-WWI, who is wanted for murder and will be joining up with a friend of yours on a train (The Orient Express) to escape the allegations.
The story is non-linear, creating an unique storyline from your successes as well as your failures, comparable to the modern adventure detective game Heavy Rain where no two playthroughs are alike.
The whole story is being played out on the express train without any exceptions. And as I mentioned, everything is in real time (but with the ability to fast forward), so if a character tells you to meet him at a certain moment, you'll need to free some time at that time. The different dialogues and interactions throughout the game are mature and intriguing, and the characters all feel surprisingly alive due to the AI, where all passengers on the train perform their daily routines including sleeping, eating, reading the paper, having conversations, playing chess and so on. It really makes you feel as if you actually embarked on that train.
The art of this game was also relatively unique, where they used real people in a 22-day long live shoot as basis for the cartoon-like characters, as can be seen below.
The reason for the game not being as famous as it should have been was not just because of the creativity or unique atmosphere (also as a minor criticism, both the way the story unfolds and the art takes a while to get used to, and only if you aren't conservative in terms of gameplay), but because the developers had certain problems where the marketing division quit, resulting in basically no recognition and went out of print short thereafter. It was truly a pity, because the game is one of the most amazing adventure games ever made.