EPTSmall pox (very harmful, vaccinated and eradicated)
Measles (high risk of complications, very contagious, vaccinated against but making a comeback due to anti-vaxxers)
Coronavirus and You - Page 143
| Forum Index > General Forum |
Any and all updates regarding the COVID-19 will need a source provided. Please do your part in helping us to keep this thread maintainable and under control. It is YOUR responsibility to fully read through the sources that you link, and you MUST provide a brief summary explaining what the source is about. Do not expect other people to do the work for you. Conspiracy theories and fear mongering will absolutely not be tolerated in this thread. Expect harsh mod actions if you try to incite fear needlessly. This is not a politics thread! You are allowed to post information regarding politics if it's related to the coronavirus, but do NOT discuss politics in here. Added a disclaimer on page 662. Many need to post better. | ||
Firebolt145
Lalalaland34504 Posts
Small pox (very harmful, vaccinated and eradicated) Measles (high risk of complications, very contagious, vaccinated against but making a comeback due to anti-vaxxers) | ||
|
JimmiC
Canada22817 Posts
| ||
|
Artisreal
Germany9235 Posts
As well as face shields are used to prevent deposition on with face with subsequent smearing into eyes and nose as well as to prevent direct virus immission into the eyes. | ||
|
JimmiC
Canada22817 Posts
| ||
|
pmh
1416 Posts
On the media people are talking about what is effectively rationing acces to public transport (you will need to get priority/acces from possibly an app,for example because the work you do is important,to make use of the transport at certain times). At the same time they will try spreading out the crowd by having different sectors of the economy start the work day at different times. People will also have to keep their distance from other passengers,for example by making a large amount of seats unavailable. Capacity will be about ~25% of normal capacity max which creates financial problems for the operators (mostly semi or full government operated). It is difficult to see this work properly in reality,let alone for a long time. Shops for example (most of which have not been closed) depend on customers and for shops in the big cities many customers come with public transport (and shopping is unlikely to get you priority to make use of the transport). Museums might open again but then if people can not go to the museum because they can not use public transport it doesnt help that much. Restricted public transport in the netherlands will be pretty much a bottleneck for almost any economic activity. So many sectors of the economy depend on a lot of customers moving around,specially the sectors that now have been closed (restaurants,bars,movie theaters,museums). I do hope they will find a different way to re-open public transport which wont limit capacity as much. For example the use of face masks,temperature checks when entering,extensive cleaning by special crews throughout the day. 25% capacity will be to much of a restriction to many economic activities and does not seem to be a realistic option for a long period of time. | ||
|
Emnjay808
United States10665 Posts
| ||
|
CuddlyCuteKitten
Sweden2834 Posts
On April 30 2020 08:16 Emnjay808 wrote: Any reliable sources talking about the steps that would be taken to test for antibodies? Surely they wouldn’t rush out a vaccine and distribute it to people who may or may not have antibodies. Seems weird. Yes. National agencies in Sweden are currently evaluating 4 different kinds of test-kits. Also mentions that KTH (university in Sweden) claims to have a test that is 100 % effective that they are validating themselves. There are currently a LOT of different tests available so that's not the problem. The problem is that many are bad and unreliable. Some are probably good. So we are in the stage of validation. Wait a few weeks and there will almost certainly be a several good test that are validated and ready for mass production worldwide. https://www.svt.se/nyheter/vetenskap/folkhalsomyndigheten-utvarderar-antikroppstester-for-covid-19 More good news! It seems you do get immune after having Corona (I have seen mentions of German, South Korean and Chinese studies). Good both for heard immunity and a future vaccines. https://www.washingtontimes.com/news/2020/apr/27/who-walks-back-no-evidence-claim-coronavirus-immun/ And even more good news! Seems like remdesevir is a possible treatment. It's not perfect but 30 % reduced treatment time is kind of big when it comes to reducing the load on healthcare and even a small drop in mortality is nice. https://www.sydsvenskan.se/2020-04-29/handelsstopp-i-coronaaktie | ||
|
Danglars
United States12133 Posts
Scientists on Wednesday announced the first effective treatment against the coronavirus — an experimental drug that can speed the recovery of COVID-19 patients — in a major medical advance that came as the economic gloom caused by the scourge deepened in the U.S. and Europe. The U.S. government said it is working to make the antiviral medication remdesivir available to patients as quickly as possible. “What it has proven is that a drug can block this virus,” said Dr. Anthony Fauci, the government’s top infectious-disease expert. “This will be the standard of care.” [...] California-based biotech company Gilead Sciences and the U.S. government reported that in a major study, remdesivir shortened the time it takes for COVID-19 patients to recover by four days on average — from 15 days to 11. Also, a trend toward fewer deaths was seen among those on the drug, Fauci said. AP The NYT reports the FDA is going to emergency authorize it for treatment. It's a standard antiviral nucleotide analog (the high presence of chemists in this forum will recognize the drug's similarity to adenosine) that hurts replication and hence viral production in cells. It's pretty cool stuff in the world of treating this disease prior to an effective vaccine. The results look promising, but are short of more rigorous studies. | ||
|
Lmui
Canada6223 Posts
On April 30 2020 15:04 Danglars wrote: Gilead Sciences remdesivir is being touted as an effective drug to quicken recovery and lower deaths. AP The NYT reports the FDA is going to emergency authorize it for treatment. It's a standard antiviral nucleotide analog (the high presence of chemists in this forum will recognize the drug's similarity to adenosine) that hurts replication and hence viral production in cells. It's pretty cool stuff in the world of treating this disease prior to an effective vaccine. The results look promising, but are short of more rigorous studies. Studies look promising, my guess: In the USA, it's going to be $1000+ for a 2 week supply without insurance. The catch is that you have to start dosing early - during onset of initial symptoms, or even before at exposure time to see maximal benefit. If it can limit the worst of the symptoms, Gilead is going to make a killing off of it. Initial results are that it also dropped mortality - 8.0% on the drug died vs. 11.6% receiving placebo https://en.wikipedia.org/wiki/Remdesivir Looks like it was primarily as an antiviral against Ebola. No news yet on scalability. Wikipedia has this: On 23 March 2020, Gilead voluntarily suspended access for compassionate use (excepting cases of critically ill children and pregnant women), for reasons related to supply, citing the need to continue to provide the agent for testing in clinical trials. so even with this news, I'd guess 60-90 days to even begin manufacturing this at a visible scale, even with 16/7 work to stand up the manufacturing lines, and with ~80k new cases a day worldwide now, it'll likely be reserved for only high risk populations. Specifically, medical professionals, elderly, immunocompromised and the rich. Edit:: A more updated, and layman oriented article: https://arstechnica.com/science/2020/04/first-treatment-for-sars-cov-2-shortens-recovery-time/ | ||
|
warding
Portugal2396 Posts
https://www.gilead.com/purpose/advancing-global-health/covid-19/working-to-supply-remdesivir-for-covid-19 It might be OK if it's meant mainly for severe cases. According to worldmeter there are around 60k people in ICUs (marked severe/critical cases) at the peak of this first wave. | ||
|
Vindicare605
United States16124 Posts
Los Angeles Mayor Eric Garcetti said Wednesday that all city and county residents who want a coronavirus test can now get one for the first time since COVID-19 cases began appearing there in January.,, ...Now, any L.A. city or county resident who wants a test can make an appointment and get one at one of dozens of testing sites in the area, the mayor said at a news conference on Wednesday. So happy about this. I'm just in general super pleased with how my city, my state and my county has reacted to everything. Perhaps this means that we can open the city up again once enough people are tested. I know that I'd love to get tested myself, just for a peace of mind. I just made my appointment. I can't express how much of a peace of mind it is that I'll be able to just know whether or not I have it. | ||
|
Artisreal
Germany9235 Posts
| ||
|
Vindicare605
United States16124 Posts
On April 30 2020 19:28 Artisreal wrote: Peace of mind if you've been infected? Otherwise it didn't help you much as you can get it anytime? If everyone gets tested at least they'll know whether or not they need to be self-isolating. It's an important first step. As of now we are all self-isolating whether we have the disease or not. | ||
|
Acrofales
Spain18348 Posts
On April 30 2020 15:54 Lmui wrote: Studies look promising, my guess: In the USA, it's going to be $1000+ for a 2 week supply without insurance. The catch is that you have to start dosing early - during onset of initial symptoms, or even before at exposure time to see maximal benefit. If it can limit the worst of the symptoms, Gilead is going to make a killing off of it. Initial results are that it also dropped mortality - 8.0% on the drug died vs. 11.6% receiving placebo https://en.wikipedia.org/wiki/Remdesivir Looks like it was primarily as an antiviral against Ebola. No news yet on scalability. Wikipedia has this: so even with this news, I'd guess 60-90 days to even begin manufacturing this at a visible scale, even with 16/7 work to stand up the manufacturing lines, and with ~80k new cases a day worldwide now, it'll likely be reserved for only high risk populations. Specifically, medical professionals, elderly, immunocompromised and the rich. Edit:: A more updated, and layman oriented article: https://arstechnica.com/science/2020/04/first-treatment-for-sars-cov-2-shortens-recovery-time/ Two things to take into account here and not jump on this as conclusive that remdesivir does anything at all. (1) Everybody is rushing to test their medicine with even the tiniest chance of working to slow/stop Covid. I don't think that under such conditions having a p cutoff at 0.05 is enough. A p=0.05 basically means that 1 in 20 times such a result can be seen due to random chance even if the populations are exactly the same. So if there are 20 trials for different drugs, all of which do *nothing*, the expected outcome would be that one of them looks like it does something (it's still random, so it could be none of them do, or even all 20 of them do, but the p-value simply says that the chance of getting a result like this even if there is no difference is 1 in 20). There are a lot more than 20 potential drugs being tested vs Covid right now... (2) Gilead conducted the trial themselves and have serious economic interest in a positive outcome. It wouldn't be the first time a pharmaceutical company "finessed" the conclusions from a trial to look more positive than it merits. Steps have been taken to ensure the raw data from clinical trials is opened up. I do not know if that is the case here as well. If they have, then I would wait for an independent organization to doublecheck that there is no funny business going on here. If they haven't then I would be hesitant to take this trial at face value. That said, having any kind of weapon to help fight off this virus is going to be very very welcome and I really hope this is indeed a true positive and makes treating patients a little bit easier. | ||
|
Emnjay808
United States10665 Posts
Still an alarming amount of people don’t realize the true purpose of lockdown. In some cases (for respective states) it’s starting to do more harm than good. We need to establish a balance. This falls on the governors to take action appropriate to economy revitalization and keeping hospital occupancy at a manageable rate. | ||
|
Simberto
Germany11913 Posts
I understand opening up further once stuff is going well. But stuff isn't going well in the US yet. You just passed a Vietnam War in deaths. More than 40% of the worldwide active infections are in the US. Your active infected numbers still rise every day. What in that is the signal that says that now is the time to open up again? I honestly think that we might be opening up a bit prematurely in Germany, and we have had declining numbers of active infected for weeks now. Opening up in the US sounds just insane with your numbers. | ||
|
maybenexttime
Poland5837 Posts
| ||
|
Emnjay808
United States10665 Posts
Open up the gates a little. I’m not advocating theaters and bars to open up lol, and obviously everyone should still be wearing masks and maintaining 6ft etc. We need to find that balance because everyone has got to develop antibodies sooner or later (and I recently read that reinfection is not possible, great news). Keeping a strict, constant, untempered lockdown would likely hurt us economically in the long run and if that can be avoided without compromising COVID numbers then it should definitely be acted upon. | ||
|
Vivax
22406 Posts
On April 30 2020 21:12 maybenexttime wrote: What is more, misinformation is in full swing. My family from the US is frequently sharing all sorts of coronavirus-related nonsense on Facebook, and they're university-educated people. One of them actually works in academia... Recently my aunt shared a video by two ER doctors from California who claim that the lethality of the virus is much lower because they extrapolated the percentage of positive tests to the whole population of California. Now Fox News is pushing this bullshit in its propaganda. Yeah, it's in full swings in both camps. Our chancellor basically got caught on tape saying 'we have to make people afraid' and a coroner I had an online teaching session with showed that the R0 of the infection was already receding before the lockdowns. This just purports what I was thinking from the start: First they reacted too late, then they reacted too harshly. I think the measures are justified for something we don't know too much about but the handling is abysmal. | ||
|
Artisreal
Germany9235 Posts
Because people kept the fuck away from each other. | ||
| ||
