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Boundz(DarKo)
Profile Joined March 2009
5311 Posts
Last Edited: 2011-11-06 11:56:32
November 06 2011 11:56 GMT
#12521
Didn't know where else to put this, but as this might sound a bit weird I think it will fit nicely into this thread.

In short: I am going to fuck Thorzains younger sister.

Later...
Opera
Profile Joined March 2011
France469 Posts
November 06 2011 11:56 GMT
#12522
Volcano is the bomb ! I discovered it at the Bluebird in Amsterdam like 4 years ago. I think I'm going to buy one.
It ain't over till it's over
Boundz(DarKo)
Profile Joined March 2009
5311 Posts
November 06 2011 11:57 GMT
#12523
On November 06 2011 20:56 Opera wrote:
Volcano is the bomb ! I discovered it at the Bluebird in Amsterdam like 4 years ago. I think I'm going to buy one.

You save on the weed and it's obv alot healthier for you too. But they aren't very cheap :/
Orfen
Profile Joined June 2011
Greece16 Posts
November 06 2011 12:03 GMT
#12524
Is there any post that sums up all the pros that toke/posted here? I remember seeing djwheat post here, is there anyone else?
two.watup
Profile Joined March 2011
United States371 Posts
November 06 2011 12:08 GMT
#12525
On November 06 2011 20:57 Boundz(DarKo) wrote:
Show nested quote +
On November 06 2011 20:56 Opera wrote:
Volcano is the bomb ! I discovered it at the Bluebird in Amsterdam like 4 years ago. I think I'm going to buy one.

You save on the weed and it's obv alot healthier for you too. But they aren't very cheap :/

Yeah it's like $500. I've never vaped, so I ordered a shitty $40 on amazon just in case it isn't for me :D
FallDownMarigold
Profile Blog Joined December 2010
United States3710 Posts
Last Edited: 2011-11-06 12:54:48
November 06 2011 12:45 GMT
#12526
On November 02 2011 20:13 Epigon wrote:
Show nested quote +
On October 31 2011 06:47 LagT_T wrote:
On October 31 2011 00:41 SnetteL wrote:
On October 31 2011 00:37 Grimmyman123 wrote:
How do you know a SC2 player is stoned out of his mind? His APM drops to 1.


I actually play pretty smooth when I'm high, mechanics are alright, decision making 'slightly' slower.


If I had a dollar for every time I tunneled vision on a battle staring at the pretty lazerz :$



Dude, you guys should try to clear your mind before getting high and tell yourself almost all of the socially learned stereotypes about weed are false. Weed helps your brain fire differently, not worse, it actually helps you fire new synapses. I have found that knowing that I can ignore what people say it does to you and use it as almost a performance enhancing drug. If you have the right mindset while using it, and are using a sativa, I find you can use it to get a lot better at almost anything.

Edit: The reason I say this is because we have to come together as pot heads and use it as a tool of self improvement, therefore it's social usefulness can not be questioned. If we use it to help us improve ourselves it is only a matter of time before the stereotypes about it are a thing of the past and people know the truth instead of propaganda from fucking 50 years ago.


It's cool that your anecdotal experience says weed makes you better at certain things. Here's what some research says though:

Smoking weed lets THC act on your CB1 receptors at the brain. Normally, the main endogenous ligand for CB1 receptor is anandamide, a hormone involved in a variety of different signaling pathways. Anandamide is associated with appetite and "forgetting" pathways.

In one study, researchers constitutively inactivated CB1 receptors. In other words, it would be like making it so that you turned off the effect anandamide normally has. What should be obvious at this point is that the researchers developed a model for looking at the first layer of the mechanism in your brain that responds to THC from weed. They completely knocked out CB1 responsiveness to anandamide, which implies they generated a mouse line unresponsive to THC. Next, they performed behavioral and functional testing. They found that CB1-/- mice, or mice that are physically incapable of being stimulated by THC, retained aversive memories forever. What I mean here is that they shocked normal, wildtype mice each time they sounded a high frequency alarm. The normal mice learned to associate the sound with pain, and thus they responded to the sound just as they did to the pain stimulus after they got used to the sound. Even when the painful stimulus was not applied, the mice responded as if it was. For about a week after the painful stimulus was stopped being administered along with the sound, the normal mice would respond to it just the same. Now for the really interesting part:

After about a week, these normal mice began to "forget" about the painful sound association, and they stopped responding negatively to the sound alarm without the pain stimulus. In other words, they were able to forget about the aversive relationship between the painful shock and the alarm sound that came with it initially. However, they did the same experiments on CB1 receptor null mice. These mice had no anandamide receptor activity, which as I stated is the endogenous ligand that activates the same receptors activated by THC from weed. So how did these mice respond to the learning experiment? Well, they too did not like the painful shock stimulus. They too did not like the alarm sound, as it reminded them of the shock even when the shock was withheld from the alarm sound. The difference? These mice NEVER forgot about the painful association with the alarm sound. Even after months, these mice still retained these aversive memories.

Discussion. So? What does that imply? Well, it has implications on memory for starters. Bad or good? Well, it's useful to know that the medical world actually used those mice studies as a basis for considering marijuana as an anti-traumatic experiences treatment. It's still being studied extensively now as an option. Imagine if we could help people to gain the ability to "forget" about aversive correlations and memories? This could immensely help war veterans with post-traumatic stress disorder. What about the bad? Well, there is a correlation with loss of short term memory ability too, as demonstrated by the data.

Where does this fit into what you said about weed "helping" you perform? Well, let's think about it. Now that we've elucidated a bit of what THC is actually DOING in your brain (there is still much we don't know...), let's see if we can define how it might be improving function. I'm curious as to what you come up with, because right now I can't come up with any ideas for how it might increase brain function or whatever. In fact, it seems that it might hamper your cognitive processes due to the CB1 effects!


Edit: Forgot to add. It would also be a useful study if one examined the effects of constitutively activating CB1 receptor activity. And that's exactly what researchers did after the CB1-/- mice experiments. Basically, they created mice that ALWAYS have their CB1 receptors activated. Remember, CB1 is the receptor at the brain that is activated by THC molecules from weed, or by endogenous anandamide ligand. What did they call these mice? The mice were dubbed "stoner mice". These mice were hilarious, and maybe later I'll try to find some of the research data including videos of how these "stoner mice" behaved. In short, a lot of observations were made regarding their various behavioral characteristics. None of these observations suggested any obvious increased ability to do anything. As a result, I would argue that your seemingly newfound and improved ability to do something while high on THC is not a direct result of what THC is doing to your brain. Rather, it's got to be because of something else. Maybe you think differently while high, and THAT is what improves whatever particular thing you are doing on some other level of cognition. However, that said, you still experience the delays and other "slightly negative" effects of weed as a result of CB1 activity alteration.
youngminii
Profile Blog Joined May 2010
Australia7514 Posts
Last Edited: 2011-11-06 12:50:20
November 06 2011 12:49 GMT
#12527
^ THC affects more than one type of receptor.

On November 06 2011 20:56 Boundz(DarKo) wrote:
Didn't know where else to put this, but as this might sound a bit weird I think it will fit nicely into this thread.

In short: I am going to fuck Thorzains younger sister.

Later...

Keep us updated.
lalala
FallDownMarigold
Profile Blog Joined December 2010
United States3710 Posts
Last Edited: 2011-11-06 13:05:48
November 06 2011 12:56 GMT
#12528
^ The receptor to which THC binds most strongly and whose effects are observed most readily is the CB1 receptor. This receptor is also well characterized based on other studies, thus, provides a reasonable avenue of examining the physiological effect of THC on animals.

edit: Because you mentioned it and I was curious as to why I hadn't been informed of it when I was taught about CB1, I went ahead and looked around for other receptors that have affinity for THC. I could only find CB2, a closely related receptor. What other receptors are you talking about? Be specific and describe their known function because I'm curious thanks

edit2: Went ahead and did more searching. It turns out you are right! THC also displays lower affinity to GlyR (glycine receptor). Glycine receptors are involved in generating inhibitory postsynaptic potentials. Great! Glycine is the most common IPSP neurotransmitter in the brain, thus pointing out that THC affects GlyR to a lesser degree is insignificant, or at least much less clear. In short, if you consider GlyR effects from THC, you open up an enormous field of possibilities of slighter effects from THC. Look into glycine-related IPSPs and what they govern.
Lann555
Profile Joined February 2010
Netherlands5173 Posts
November 06 2011 13:01 GMT
#12529
I'm considering buying a vaporizer myself. I haven't used one in like six years and then it was only once, so I don't remember what it was like.

My main question is: Is there a difference in the high you get from vaporized cannabis, compared to smoking it?
Fantasy Fan! Gogogo vultures
FallDownMarigold
Profile Blog Joined December 2010
United States3710 Posts
November 06 2011 13:12 GMT
#12530
On November 06 2011 22:01 Lann555 wrote:
I'm considering buying a vaporizer myself. I haven't used one in like six years and then it was only once, so I don't remember what it was like.

My main question is: Is there a difference in the high you get from vaporized cannabis, compared to smoking it?


Interesting question while I'm poking around here. I don't know from experience, but here's what makes sense. Vaporizers work by heating up just hot enough to vaporize the THC (active component of weed). When you get high this way, you are inhaling THC molecules rather than THC plus all the additional particulates and colloids generated when you actually BURN the plant matter with a flame. Thus, the psychotropic effects from weed should be similar or the same.

Here's where it gets tricky. There are also other molecules in weed that might contribute to your desired high or feeling or whatever it is that you want from it. These molecules, or cannabinoids, might not vaporize at the same temperature you use to vaporize the THC molecules out of the weed. Therefore your high might not be quite the same, if one assumes that THC is not the only contributing factor. Also you might consider the fact that vaporizing your weed might not "burn" all the THC out of it. There could be residual THC as the plant matter is not entirely burned up. So in that sense maybe you'd get slightly less THC, and slightly less high.


Now take all that nerdy shit and throw it aside! I've heard a vaporizer will get you higher than other methods of smoking. That's just what I've heard though. No reason. I kinda hate giving answers with no logical reasoning, so that's why I included a lot of shit about how vaporizing stuff works.
Linkirvana
Profile Blog Joined November 2010
Netherlands365 Posts
November 06 2011 13:12 GMT
#12531
I bought a vaporizer awhile ago, used it for about 2 months.

I quit smoking at the same time the vaporizer arrived, switching to just vaporizing weed. I did smoke joints with my friends occasionally during the weekends, and found that the added effect that nicotine gives me was too nice to leave out. I started smoking again after those 2 months, and haven't used my vaporizer since.

A vaporizer gets you proper high, but the lack of nicotine and the lack of the "smoking experience" can leave you unsatisfied using just a vaporizer.

I would guess this wouldn't affect you if you are not an addict though, since I feel that what I miss in vaporizing is just between the ears. (Which I suppose is caused by my addiction)
Boundz(DarKo)
Profile Joined March 2009
5311 Posts
November 06 2011 13:13 GMT
#12532
On November 06 2011 21:49 youngminii wrote:
Keep us updated.

Lol yeah I will... but perhaps not with pictures
Grettin
Profile Joined April 2010
42381 Posts
November 06 2011 13:17 GMT
#12533
On November 06 2011 22:13 Boundz(DarKo) wrote:
Show nested quote +
On November 06 2011 21:49 youngminii wrote:
Keep us updated.

Lol yeah I will... but perhaps not with pictures


Its okay, video is better anyway.
"If I had force-fields in Brood War, I'd never lose." -Bisu
Boundz(DarKo)
Profile Joined March 2009
5311 Posts
November 06 2011 15:03 GMT
#12534
On November 06 2011 22:17 Grettin wrote:
Show nested quote +
On November 06 2011 22:13 Boundz(DarKo) wrote:
On November 06 2011 21:49 youngminii wrote:
Keep us updated.

Lol yeah I will... but perhaps not with pictures


Its okay, video is better anyway.

You do realize what you are asking for, right?
McDylan
Profile Joined August 2011
Canada32 Posts
November 06 2011 16:06 GMT
#12535
Mind Fuck.
Wrongspeedy
Profile Blog Joined August 2010
United States1655 Posts
Last Edited: 2011-11-06 16:32:21
November 06 2011 16:31 GMT
#12536
+ Show Spoiler +
On November 06 2011 21:45 FallDownMarigold wrote:
Show nested quote +
On November 02 2011 20:13 Epigon wrote:
On October 31 2011 06:47 LagT_T wrote:
On October 31 2011 00:41 SnetteL wrote:
On October 31 2011 00:37 Grimmyman123 wrote:
How do you know a SC2 player is stoned out of his mind? His APM drops to 1.


I actually play pretty smooth when I'm high, mechanics are alright, decision making 'slightly' slower.


If I had a dollar for every time I tunneled vision on a battle staring at the pretty lazerz :$



Dude, you guys should try to clear your mind before getting high and tell yourself almost all of the socially learned stereotypes about weed are false. Weed helps your brain fire differently, not worse, it actually helps you fire new synapses. I have found that knowing that I can ignore what people say it does to you and use it as almost a performance enhancing drug. If you have the right mindset while using it, and are using a sativa, I find you can use it to get a lot better at almost anything.

Edit: The reason I say this is because we have to come together as pot heads and use it as a tool of self improvement, therefore it's social usefulness can not be questioned. If we use it to help us improve ourselves it is only a matter of time before the stereotypes about it are a thing of the past and people know the truth instead of propaganda from fucking 50 years ago.


It's cool that your anecdotal experience says weed makes you better at certain things. Here's what some research says though:

Smoking smoke weed lets THC act on your CB1 receptors at the brain. Normally, the main endogenous ligand for CB1 receptor is anandamide, a hormone involved in a variety of different signaling pathways. Anandamide is associated with appetite and "forgetting" pathways.

In one study, researchers constitutively inactivated CB1 receptors. In other words, it would be like making it so that you turned off the effect anandamide normally has. What should be obvious at this point is that the researchers developed a model for looking at the first layer of the mechanism in your brain that responds to THC from weed. They completely knocked out CB1 responsiveness to anandamide, which implies they generated a mouse line unresponsive to THC. Next, they performed behavioral and functional testing. They found that CB1-/- mice, or mice that are physically incapable of being stimulated by THC, retained aversive memories forever. What I mean here is that they shocked normal, wildtype mice each time they sounded a high frequency alarm. The normal mice learned to associate the sound with pain, and thus they responded to the sound just as they did to the pain stimulus after they got used to the sound. Even when the painful stimulus was not applied, the mice responded as if it was. For about a week after the painful stimulus was stopped being administered along with the sound, the normal mice would respond to it just the same. Now for the really interesting part:

After about a week, these normal mice began to "forget" about the painful sound association, and they stopped responding negatively to the sound alarm without the pain stimulus. In other words, they were able to forget about the aversive relationship between the painful shock and the alarm sound that came with it initially. However, they did the same experiments on CB1 receptor null mice. These mice had no anandamide receptor activity, which as I stated is the endogenous ligand that activates the same receptors activated by THC from weed. So how did these mice respond to the learning experiment? Well, they too did not like the painful shock stimulus. They too did not like the alarm sound, as it reminded them of the shock even when the shock was withheld from the alarm sound. The difference? These mice NEVER forgot about the painful association with the alarm sound. Even after months, these mice still retained these aversive memories.

Discussion. So? What does that imply? Well, it has implications on memory for starters. Bad or good? Well, it's useful to know that the medical world actually used those mice studies as a basis for considering marijuana as an anti-traumatic experiences treatment. It's still being studied extensively now as an option. Imagine if we could help people to gain the ability to "forget" about aversive correlations and memories? This could immensely help war veterans with post-traumatic stress disorder. What about the bad? Well, there is a correlation with loss of short term memory ability too, as demonstrated by the data.

Where does this fit into what you said about weed "helping" you perform? Well, let's think about it. Now that we've elucidated a bit of what THC is actually DOING in your brain (there is still much we don't know...), let's see if we can define how it might be improving function. I'm curious as to what you come up with, because right now I can't come up with any ideas for how it might increase brain function or whatever. In fact, it seems that it might hamper your cognitive processes due to the CB1 effects!


Edit: Forgot to add. It would also be a useful study if one examined the effects of constitutively activating CB1 receptor activity. And that's exactly what researchers did after the CB1-/- mice experiments. Basically, they created mice that ALWAYS have their CB1 receptors activated. Remember, CB1 is the receptor at the brain that is activated by THC molecules from weed, or by endogenous anandamide ligand. What did they call these mice? The mice were dubbed "stoner mice". These mice were hilarious, and maybe later I'll try to find some of the research data including videos of how these "stoner mice" behaved. In short, a lot of observations were made regarding their various behavioral characteristics. None of these observations suggested any obvious increased ability to do anything. As a result, I would argue that your seemingly newfound and improved ability to do something while high on THC is not a direct result of what THC is doing to your brain. Rather, it's got to be because of something else. Maybe you think differently while high, and THAT is what improves whatever particular thing you are doing on some other level of cognition. However, that said, you still experience the delays and other "slightly negative" effects of weed as a result of CB1 activity alteration.


So mice shouldn't weed? Wtf does that experiment have to do with humans? I think I have also read that its proven that forgetfulness from weed smoking is short term and not permanent for those using moderately. Sure glad some scientists could waste some time and money doing that experiment that proves nothing...
It is better to be a human dissatisfied than a pig satisfied; better to be Socrates dissatisfied than a fool satisfied.- John Stuart Mill
Grettin
Profile Joined April 2010
42381 Posts
Last Edited: 2011-11-06 17:14:27
November 06 2011 17:13 GMT
#12537
On November 07 2011 00:03 Boundz(DarKo) wrote:
Show nested quote +
On November 06 2011 22:17 Grettin wrote:
On November 06 2011 22:13 Boundz(DarKo) wrote:
On November 06 2011 21:49 youngminii wrote:
Keep us updated.

Lol yeah I will... but perhaps not with pictures


Its okay, video is better anyway.

You do realize what you are asking for, right?


That depends. :p
+ Show Spoiler +
I was joking



On November 07 2011 01:06 McDylan wrote:
Mind Fuck.


Doesn't work for me. "Friend, there was a problem loading the url. Please go back and try again."
"If I had force-fields in Brood War, I'd never lose." -Bisu
McDylan
Profile Joined August 2011
Canada32 Posts
Last Edited: 2011-11-07 05:33:42
November 07 2011 00:50 GMT
#12538
On November 07 2011 01:06 McDylan wrote:
Mind Fuck.





http://www.yooouuutuuube.com/v/?width=192&height=120&yt=wtjZOf0WmdE&flux=0&direction=rand

Better?
FallDownMarigold
Profile Blog Joined December 2010
United States3710 Posts
Last Edited: 2011-11-07 03:17:42
November 07 2011 03:14 GMT
#12539
On November 07 2011 01:31 Wrongspeedy wrote:
+ Show Spoiler +
On November 06 2011 21:45 FallDownMarigold wrote:
Show nested quote +
On November 02 2011 20:13 Epigon wrote:
On October 31 2011 06:47 LagT_T wrote:
On October 31 2011 00:41 SnetteL wrote:
On October 31 2011 00:37 Grimmyman123 wrote:
How do you know a SC2 player is stoned out of his mind? His APM drops to 1.


I actually play pretty smooth when I'm high, mechanics are alright, decision making 'slightly' slower.


If I had a dollar for every time I tunneled vision on a battle staring at the pretty lazerz :$



Dude, you guys should try to clear your mind before getting high and tell yourself almost all of the socially learned stereotypes about weed are false. Weed helps your brain fire differently, not worse, it actually helps you fire new synapses. I have found that knowing that I can ignore what people say it does to you and use it as almost a performance enhancing drug. If you have the right mindset while using it, and are using a sativa, I find you can use it to get a lot better at almost anything.

Edit: The reason I say this is because we have to come together as pot heads and use it as a tool of self improvement, therefore it's social usefulness can not be questioned. If we use it to help us improve ourselves it is only a matter of time before the stereotypes about it are a thing of the past and people know the truth instead of propaganda from fucking 50 years ago.


It's cool that your anecdotal experience says weed makes you better at certain things. Here's what some research says though:

Smoking smoke weed lets THC act on your CB1 receptors at the brain. Normally, the main endogenous ligand for CB1 receptor is anandamide, a hormone involved in a variety of different signaling pathways. Anandamide is associated with appetite and "forgetting" pathways.

In one study, researchers constitutively inactivated CB1 receptors. In other words, it would be like making it so that you turned off the effect anandamide normally has. What should be obvious at this point is that the researchers developed a model for looking at the first layer of the mechanism in your brain that responds to THC from weed. They completely knocked out CB1 responsiveness to anandamide, which implies they generated a mouse line unresponsive to THC. Next, they performed behavioral and functional testing. They found that CB1-/- mice, or mice that are physically incapable of being stimulated by THC, retained aversive memories forever. What I mean here is that they shocked normal, wildtype mice each time they sounded a high frequency alarm. The normal mice learned to associate the sound with pain, and thus they responded to the sound just as they did to the pain stimulus after they got used to the sound. Even when the painful stimulus was not applied, the mice responded as if it was. For about a week after the painful stimulus was stopped being administered along with the sound, the normal mice would respond to it just the same. Now for the really interesting part:

After about a week, these normal mice began to "forget" about the painful sound association, and they stopped responding negatively to the sound alarm without the pain stimulus. In other words, they were able to forget about the aversive relationship between the painful shock and the alarm sound that came with it initially. However, they did the same experiments on CB1 receptor null mice. These mice had no anandamide receptor activity, which as I stated is the endogenous ligand that activates the same receptors activated by THC from weed. So how did these mice respond to the learning experiment? Well, they too did not like the painful shock stimulus. They too did not like the alarm sound, as it reminded them of the shock even when the shock was withheld from the alarm sound. The difference? These mice NEVER forgot about the painful association with the alarm sound. Even after months, these mice still retained these aversive memories.

Discussion. So? What does that imply? Well, it has implications on memory for starters. Bad or good? Well, it's useful to know that the medical world actually used those mice studies as a basis for considering marijuana as an anti-traumatic experiences treatment. It's still being studied extensively now as an option. Imagine if we could help people to gain the ability to "forget" about aversive correlations and memories? This could immensely help war veterans with post-traumatic stress disorder. What about the bad? Well, there is a correlation with loss of short term memory ability too, as demonstrated by the data.

Where does this fit into what you said about weed "helping" you perform? Well, let's think about it. Now that we've elucidated a bit of what THC is actually DOING in your brain (there is still much we don't know...), let's see if we can define how it might be improving function. I'm curious as to what you come up with, because right now I can't come up with any ideas for how it might increase brain function or whatever. In fact, it seems that it might hamper your cognitive processes due to the CB1 effects!


Edit: Forgot to add. It would also be a useful study if one examined the effects of constitutively activating CB1 receptor activity. And that's exactly what researchers did after the CB1-/- mice experiments. Basically, they created mice that ALWAYS have their CB1 receptors activated. Remember, CB1 is the receptor at the brain that is activated by THC molecules from weed, or by endogenous anandamide ligand. What did they call these mice? The mice were dubbed "stoner mice". These mice were hilarious, and maybe later I'll try to find some of the research data including videos of how these "stoner mice" behaved. In short, a lot of observations were made regarding their various behavioral characteristics. None of these observations suggested any obvious increased ability to do anything. As a result, I would argue that your seemingly newfound and improved ability to do something while high on THC is not a direct result of what THC is doing to your brain. Rather, it's got to be because of something else. Maybe you think differently while high, and THAT is what improves whatever particular thing you are doing on some other level of cognition. However, that said, you still experience the delays and other "slightly negative" effects of weed as a result of CB1 activity alteration.


So mice shouldn't weed? Wtf does that experiment have to do with humans? I think I have also read that its proven that forgetfulness from weed smoking is short term and not permanent for those using moderately. Sure glad some scientists could waste some time and money doing that experiment that proves nothing...


Oh lol sorry. Mice and humans have basically identical genomes, with only slight differences. As such studying genes, receptors, and all that good molecular biology in mice and other animals is a good way to find out about humans. As for wasting their time? Don't worry. What I was talking about is solid science that is in journals and has been published etc. It's "legit". In other words you calling it nonsense doesn't really matter given the weight it holds in the field!
Avaek
Profile Joined June 2011
New Zealand49 Posts
November 07 2011 03:18 GMT
#12540
after reading that krokodil thread is anyone else keen to ditch weed and try it out?
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