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Read the rules in the OP before posting, please.In order to ensure that this thread continues to meet TL standards and follows the proper guidelines, we will be enforcing the rules in the OP more strictly. Be sure to give them a re-read to refresh your memory! The vast majority of you are contributing in a healthy way, keep it up! NOTE: When providing a source, explain why you feel it is relevant and what purpose it adds to the discussion if it's not obvious. Also take note that unsubstantiated tweets/posts meant only to rekindle old arguments can result in a mod action. |
On January 16 2016 11:25 cLutZ wrote:Show nested quote +On January 16 2016 10:03 KwarK wrote:On January 16 2016 09:53 cLutZ wrote:On January 16 2016 08:52 Nyxisto wrote: giving people more direct transfers is not the correct solution nor is it really the correct message for the left. it is a strategic mistake to think that tax and spend, or debt and spend, will be the solution.
To be fair a single payer healthcare system wouldn't actually cost significantly more money for the average guy or the government because they're significantly cheaper on a per capita basis than whatever the US has going on now, it would actually lower public spending significantly. Why do conservatives not love single payer systems? Because we understand the mechanisms employed to achieve those cost savings and do not like them. But the current system is worse, surely. Health insurance is, for some reason, a tax free part of employee compensation while low income people get it gratis. For the average man, employed or unemployed, there is no difference between scrapping employer health insurance, mandating it be replaced with a pay bump and then negating most of the pay bump with a National Health Service tax and leaving things as they are. None. The exact numbers are unclear, but I would concede that for the next 5 years, this is the likely scenario (plus wait times because one of the only reasons the system is not flooded is because of high co-pays and low medicaid reimbursment rates). IMO, however, meting out care at our current levels, given the regulations on the professionals (and how much education they require) would not lower overall healthcare spending as a % of GDP by much. If you look at Medicare, it spends more than EU countries spend for caring for their 65+ populations. While the mantra is "Medicare for all" the reality, if you look at costs, is "Medicaid for all." Show nested quote +On January 16 2016 10:07 Nyxisto wrote:On January 16 2016 09:53 cLutZ wrote:On January 16 2016 08:52 Nyxisto wrote: giving people more direct transfers is not the correct solution nor is it really the correct message for the left. it is a strategic mistake to think that tax and spend, or debt and spend, will be the solution.
To be fair a single payer healthcare system wouldn't actually cost significantly more money for the average guy or the government because they're significantly cheaper on a per capita basis than whatever the US has going on now, it would actually lower public spending significantly. Why do conservatives not love single payer systems? Because we understand the mechanisms employed to achieve those cost savings and do not like them. So you acknowledge that a single payer system would be better at allocating the resources and provide a net benefit for society in terms both of cost and outcome but you'll disregard it on principle? That's pretty much fundamentalism and it's also dishonest to consider Sanders a radical if all he does it promoting the pragmatic and economically reasonable solution. No, not at all. I think it would provide a cost savings on the overall % of GDP spent on healthcare because the government would impose cost controls, just as Canada, Australia, and all EU countries already do. I actually do not think this will result in a better allocation of resources (I don't know what the optimal % of GDP healthcare spending should be), I simply know it will be lower because of the price controls. I also believe that this will substantially impede medical progress, not only in America, but worldwide. Its been argued, but its fair to say that the US market is the reason pharmaceutical drugs are developed (even if its by a German company). Also, nearly all EU countries have a reciprocity-style system where if the FDA approves a drug/device, they submit it to less testing, the US does not, basically another worldwide cost the US bears. This is just an opinion, but I'd say that healthcare has already been set back 5-10 years as a result of the nearly worldwide adoption of the EU-Socialized healthcare model, and if America had joined them in the 60s that number would be 20 years. Its a tradeoff between equality, and quality, not merely today, longterm. It is a classic seen vs. unseen problem, and I find it very strange that this is not intuitive to you.
so first it's long lines, death panels for the elderly, government cronyism. price fixing strangling the free market that could otherwise lead us to the promised land. now it's quality of care? have you ever been outside of the US?
you are aware people get older in a lot of EU countries? and other places that are not the US. and that's a damn good indicator of the QUALITY of care as well as standard of living?
maybe you believe your own CIA.
https://www.cia.gov/library/publications/the-world-factbook/rankorder/2102rank.html
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I guess his point is rather that the US is subsidizing the EU through research but I don't really know why it makes sense from an American perspective to keep doing that at the expense of their own citizens, and I'm not even sure if the US leading position in research is at all connected to the expensive healthcare system.
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On January 16 2016 11:59 Nyxisto wrote: I guess his point is rather that the US is subsidizing the EU through research but I don't really know why it makes sense from an American perspective to keep doing that at the expense of their own citizens, and I'm not even sure if the US leading position in research is at all connected to the expensive healthcare system. he's not arguing that the US research is leading because of the US market, he's arguing that every research, including the european ones are where they are because of the US market.
From what I've read on for-profit (in comparison to state financed) research in that section however makes it seem like for-profit is a lot less efficient as a whole since at some point those will just hit the emergency brake and put the remaining money into altering an already existing medicament so that they can resell it as something new if they're hitting a roadblock. That doesn't really happen with state financed research since profit is not the goal. (And while generating money, it doesn't really help with anything)
So I'd highly doubt his "the world is probably 10 years behind". The reason capitalism is so great for 99% of the things we can think of is because the monetary incentive doubles up with actually improving the product / situation / comming up with something new because the customer will obviously buy that. In the case of pharmacy with so much costs involved, especially longterm costs that aren't guaranteed to return anything those two however don't always overlap.
On the other hand, every dollar more you spend on research will bring it further even if it's less efficient so idk.
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An 85-year-old Houston lawyer filed suit Thursday asking a federal court in Texas to rule on whether Sen Ted Cruz (R-TX) is eligible to be President. It appears to be the first lawsuit challenging the Canadian-born Cruz's eligibility on the grounds that he does not meet the Constitution's "natural born citizen" requirement. But if Cruz-opponents were looking for the ideal test case to trip up his candidacy, this may not be it.
Newton B. Schwartz, Sr., who is leaning toward supporting Bernie Sanders for president, filed the lawsuit seeking a declaratory judgment in the U.S. District Court in Southern District of Texas, as reported by Bloomberg News.
The lawsuit cites recent analysis by Harvard Professor Laurence Tribe -- as well as concerns raised by C-SPAN callers and by Donald Trump -- that Cruz is not natural born. The rambling 28-page complaint brings all sorts of seemingly unrelated issues, including the Texas abortion case the Supreme Court will hear in March, the case it recently heard on public unions' fee structures and Texas Gov. Greg Abbott's call for a Constitutional Convention.
"No previous case has been presented or decided on this issue by the U.S. Supreme Court, including because in fact none arose, as here to being a case or controversy ripe for decisions as here is presented," the complaint said. "The entire nation cannot afford such constitutionally confusion and uncertainties overhangings the electorate process."
The complaint argues that Cruz's issue is very different than the "birther" theories about President Barack Obama's birth, and that past presidential candidates like George Romney -- who was born in Mexico -- were also ineligible to be president or vice president.
Source
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On January 16 2016 11:25 cLutZ wrote:Show nested quote +On January 16 2016 10:03 KwarK wrote:On January 16 2016 09:53 cLutZ wrote:On January 16 2016 08:52 Nyxisto wrote: giving people more direct transfers is not the correct solution nor is it really the correct message for the left. it is a strategic mistake to think that tax and spend, or debt and spend, will be the solution.
To be fair a single payer healthcare system wouldn't actually cost significantly more money for the average guy or the government because they're significantly cheaper on a per capita basis than whatever the US has going on now, it would actually lower public spending significantly. Why do conservatives not love single payer systems? Because we understand the mechanisms employed to achieve those cost savings and do not like them. But the current system is worse, surely. Health insurance is, for some reason, a tax free part of employee compensation while low income people get it gratis. For the average man, employed or unemployed, there is no difference between scrapping employer health insurance, mandating it be replaced with a pay bump and then negating most of the pay bump with a National Health Service tax and leaving things as they are. None. The exact numbers are unclear, but I would concede that for the next 5 years, this is the likely scenario (plus wait times because one of the only reasons the system is not flooded is because of high co-pays and low medicaid reimbursment rates). IMO, however, meting out care at our current levels, given the regulations on the professionals (and how much education they require) would not lower overall healthcare spending as a % of GDP by much. If you look at Medicare, it spends more than EU countries spend for caring for their 65+ populations. While the mantra is "Medicare for all" the reality, if you look at costs, is "Medicaid for all." Show nested quote +On January 16 2016 10:07 Nyxisto wrote:On January 16 2016 09:53 cLutZ wrote:On January 16 2016 08:52 Nyxisto wrote: giving people more direct transfers is not the correct solution nor is it really the correct message for the left. it is a strategic mistake to think that tax and spend, or debt and spend, will be the solution.
To be fair a single payer healthcare system wouldn't actually cost significantly more money for the average guy or the government because they're significantly cheaper on a per capita basis than whatever the US has going on now, it would actually lower public spending significantly. Why do conservatives not love single payer systems? Because we understand the mechanisms employed to achieve those cost savings and do not like them. So you acknowledge that a single payer system would be better at allocating the resources and provide a net benefit for society in terms both of cost and outcome but you'll disregard it on principle? That's pretty much fundamentalism and it's also dishonest to consider Sanders a radical if all he does it promoting the pragmatic and economically reasonable solution. No, not at all. I think it would provide a cost savings on the overall % of GDP spent on healthcare because the government would impose cost controls, just as Canada, Australia, and all EU countries already do. I actually do not think this will result in a better allocation of resources (I don't know what the optimal % of GDP healthcare spending should be), I simply know it will be lower because of the price controls. I also believe that this will substantially impede medical progress, not only in America, but worldwide. Its been argued, but its fair to say that the US market is the reason pharmaceutical drugs are developed (even if its by a German company). Also, nearly all EU countries have a reciprocity-style system where if the FDA approves a drug/device, they submit it to less testing, the US does not, basically another worldwide cost the US bears. This is just an opinion, but I'd say that healthcare has already been set back 5-10 years as a result of the nearly worldwide adoption of the EU-Socialized healthcare model, and if America had joined them in the 60s that number would be 20 years. Its a tradeoff between equality, and quality, not merely today, longterm. It is a classic seen vs. unseen problem, and I find it very strange that this is not intuitive to you.
You are basically valorizing Big Pharma beyond any relation to reality. No new blockbuster drugs that are widely used for common maladies without serious side effects have come out in the 21st century really. The whole pipeline has dried up and companies have started competing over IP fiefdoms rather than actually serving the public. The entire way we do medical/pharmaceutical/human science these days is fucked up and disconnected from knowledge systems that have served humanity immensely well through the millennia. We should be pouring research attention into studies about anything that improves health, including widely available substances, plants, herbs, etc., not just patentable drugs that are completely novel and have never interacted with human bodies before. This would require a complete paradigm shift towards optimal health rather than the addiction-model of treating diseases. We should be having research universities doing a different kind of science, instead of the inane incrementalist approaches they've been using, which are the natural evolution of competition among an increasingly unemployed graduate population looking for grant money that only goes to "proven" research tracks.
Your whole post is saturated with assumptions that Big Pharma will both continue to do a lot of good (i.e. through prescribing anti-depressants, ED pills, and painkillers) and that it's the only way to improve health outcomes. Most of Big Pharma's client base are addicted to a pill-machine that has co-evolved and mutually feeds off of a workforce that is afflicted with a whole series of nervous-system symptoms that the employed masses must attend to, including:
- vulnerability: the steady experience of flexibility without any form of protection
- hyperactivity: the imperative to accommodate constant availability
- simultaneity: the ability to handle at the same time the different tempi and velocities of multiple activies
- recombination: the crossings between various networks, social spaces, and available resources
- post-sexuality: the other as dildo
- fluid intimacies: the bodily production of indeterminate gender relations
- restlessness: being exposed to and trying to cope with the overabundance of communication, cooperation and interactivity
- unsettledness: the continuous experience of mobility across different spaces and time lines
- affective exhaustion: emotional exploitation, or emotion as an important element for the control of employability and multiple dependencies
- cunning: able to be deceitful, persistent, opportunistic, a trickster
(taken from work by Vassilis Tsianos and Dimitris Papadopoulos)
Add on top of these modern maladies the interactions between Big Agriculture/Food with Big Pharma and it's not surprising that health in the modern world is defined simply as the ability to work, not the ability to thrive. This is bullshit, and it's very strange to me that this is not intuitive to you.
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In light of the wave of sexual assault across Europe, whether we like them being here or not, can we take a moment to appreciate Mexican immigrants? I like enchiladas and also appreciate my sister not being raped.
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Obviously we need more medical/biological anthropological perspectives in our health care heh.
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will that lead to genetic manipulation that brings us closer to catgirls though?
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well, it's preferable to what is known as fatcat, enabled by the currently for the most part economic view of our health care.
:p
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If I remember correctly the US has significantly more mri scan's, surgeries, medication prescriptions and so on than any other developed nation often without any advantage in outcome so I'd agree that the for-profit model is creating the wrong incentives here.
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On January 16 2016 12:28 IgnE wrote:Show nested quote +On January 16 2016 11:25 cLutZ wrote:On January 16 2016 10:03 KwarK wrote:On January 16 2016 09:53 cLutZ wrote:On January 16 2016 08:52 Nyxisto wrote: giving people more direct transfers is not the correct solution nor is it really the correct message for the left. it is a strategic mistake to think that tax and spend, or debt and spend, will be the solution.
To be fair a single payer healthcare system wouldn't actually cost significantly more money for the average guy or the government because they're significantly cheaper on a per capita basis than whatever the US has going on now, it would actually lower public spending significantly. Why do conservatives not love single payer systems? Because we understand the mechanisms employed to achieve those cost savings and do not like them. But the current system is worse, surely. Health insurance is, for some reason, a tax free part of employee compensation while low income people get it gratis. For the average man, employed or unemployed, there is no difference between scrapping employer health insurance, mandating it be replaced with a pay bump and then negating most of the pay bump with a National Health Service tax and leaving things as they are. None. The exact numbers are unclear, but I would concede that for the next 5 years, this is the likely scenario (plus wait times because one of the only reasons the system is not flooded is because of high co-pays and low medicaid reimbursment rates). IMO, however, meting out care at our current levels, given the regulations on the professionals (and how much education they require) would not lower overall healthcare spending as a % of GDP by much. If you look at Medicare, it spends more than EU countries spend for caring for their 65+ populations. While the mantra is "Medicare for all" the reality, if you look at costs, is "Medicaid for all." On January 16 2016 10:07 Nyxisto wrote:On January 16 2016 09:53 cLutZ wrote:On January 16 2016 08:52 Nyxisto wrote: giving people more direct transfers is not the correct solution nor is it really the correct message for the left. it is a strategic mistake to think that tax and spend, or debt and spend, will be the solution.
To be fair a single payer healthcare system wouldn't actually cost significantly more money for the average guy or the government because they're significantly cheaper on a per capita basis than whatever the US has going on now, it would actually lower public spending significantly. Why do conservatives not love single payer systems? Because we understand the mechanisms employed to achieve those cost savings and do not like them. So you acknowledge that a single payer system would be better at allocating the resources and provide a net benefit for society in terms both of cost and outcome but you'll disregard it on principle? That's pretty much fundamentalism and it's also dishonest to consider Sanders a radical if all he does it promoting the pragmatic and economically reasonable solution. No, not at all. I think it would provide a cost savings on the overall % of GDP spent on healthcare because the government would impose cost controls, just as Canada, Australia, and all EU countries already do. I actually do not think this will result in a better allocation of resources (I don't know what the optimal % of GDP healthcare spending should be), I simply know it will be lower because of the price controls. I also believe that this will substantially impede medical progress, not only in America, but worldwide. Its been argued, but its fair to say that the US market is the reason pharmaceutical drugs are developed (even if its by a German company). Also, nearly all EU countries have a reciprocity-style system where if the FDA approves a drug/device, they submit it to less testing, the US does not, basically another worldwide cost the US bears. This is just an opinion, but I'd say that healthcare has already been set back 5-10 years as a result of the nearly worldwide adoption of the EU-Socialized healthcare model, and if America had joined them in the 60s that number would be 20 years. Its a tradeoff between equality, and quality, not merely today, longterm. It is a classic seen vs. unseen problem, and I find it very strange that this is not intuitive to you. You are basically valorizing Big Pharma beyond any relation to reality. No new blockbuster drugs that are widely used for common maladies without serious side effects have come out in the 21st century really. The whole pipeline has dried up and companies have started competing over IP fiefdoms rather than actually serving the public. The entire way we do medical/pharmaceutical/human science these days is fucked up and disconnected from knowledge systems that have served humanity immensely well through the millennia. We should be pouring research attention into studies about anything that improves health, including widely available substances, plants, herbs, etc., not just patentable drugs that are completely novel and have never interacted with human bodies before. This would require a complete paradigm shift towards optimal health rather than the addiction-model of treating diseases. We should be having research universities doing a different kind of science, instead of the inane incrementalist approaches they've been using, which are the natural evolution of competition among an increasingly unemployed graduate population looking for grant money that only goes to "proven" research tracks. Your whole post is saturated with assumptions that Big Pharma will both continue to do a lot of good (i.e. through prescribing anti-depressants, ED pills, and painkillers) and that it's the only way to improve health outcomes. Most of Big Pharma's client base are addicted to a pill-machine that has co-evolved and mutually feeds off of a workforce that is afflicted with a whole series of nervous-system symptoms that the employed masses must attend to, including: - vulnerability: the steady experience of flexibility without any form of protection
- hyperactivity: the imperative to accommodate constant availability
- simultaneity: the ability to handle at the same time the different tempi and velocities of multiple activies
- recombination: the crossings between various networks, social spaces, and available resources
- post-sexuality: the other as dildo
- fluid intimacies: the bodily production of indeterminate gender relations
- restlessness: being exposed to and trying to cope with the overabundance of communication, cooperation and interactivity
- unsettledness: the continuous experience of mobility across different spaces and time lines
- affective exhaustion: emotional exploitation, or emotion as an important element for the control of employability and multiple dependencies
- cunning: able to be deceitful, persistent, opportunistic, a trickster
(taken from work by Vassilis Tsianos and Dimitris Papadopoulos) Add on top of these modern maladies the interactions between Big Agriculture/Food with Big Pharma and it's not surprising that health in the modern world is defined simply as the ability to work, not the ability to thrive. This is bullshit, and it's very strange to me that this is not intuitive to you.
Yeah, there's a bunch of shitty drugs that fix one problem but ending causing or surfacing a second one, but that's a result of many Americans having absolute shit health habits. These "blockbuster" drugs are generally pretty simple molecules with wide spectrum impact, thus they have side effects, etc. It sucks that their net contribution to health is so low, but you can't 100% blame big pharma. There was demand for diabetes, heart disease, cholesterol drugs and they filled it.
I hate when people say "no blockbuster drugs have come out recently". It's actually a pretty ignorant statement to be made. Yes, we came out with some cool pharmaceuticals, some of which worked really great, some of which worked kind of okay and some of which were thalidomide. However, we got those first because they were the easy ones.
Look at HIV: no cure, but we made vaccines and a lot of treatments, and we're getting specific drugs for specific people, strains and stages that are working better and better. So we got better there, right? We managed to rush through some treatments for Ebola, so that was pretty cool as well. Our ability to cure a lot of things has been improving, and that hasn't slowed down.
But there's a lot of hard stuff. Like cancer: like cars, we're, unfortunately, like cars-- still using the same technology-- chemo for the former, combustion for the last. It's really hard to find a better solution. However, we're getting there. Jimmy Carter was supposed to be dead after his cancer metastasized, but he got some treatment which completely put him in remission. That's insane. If you read The Emperor of All Maladies (a great book) or some shorter pieces of cancer, you'll begin to understand the enormity of the problem, the effort that has gone in, and how far apart the true successes and steps forward are.
I worked at pretty much every level of research, from basic bench to Stage 4 clinical. There is a lot of cool shit I've seen in government and government labs. However, they can only take it so far. Once they've got a good proof of concept, they license it to a biotech or pharma company which bears the majority of the risk and costs for a drug. One clinical trial I was involved in cost $4,000 a month per patient for 1,200 participants (and still recruiting)-- that's $4.8M a month on a bet that, on average, has a 10% chance to pan out.
But like cars, I believe we're at the edge of a big discovery. For cars we've got electric and hybrids coming in (though sadly not hover cars). Progress has been slow and is still slow, but we're going to fucking do it.
R&D is not a linear process. It is expensive and full of failures. It used to be you could have a drug with a target market of 10,000,000. New illnesses have target populations of 10,000. You have to amortize all the failures for 10,000,000 into 10,000,000. Look, drug prices are ridiculous. However, acknowledge that R&D is expensive. This is further compounded by the fact that the US is bearing most of the burden.
Look at Solvadi, a Hep C drug made by Gilead. In the US, thousands of dollars. They basically give to Egypt (which has some ridiculous percentage of the population with Hep C) for free. Why? Because we're the only market that will pay thousands. We subsidize the rest of the world out of our own, and collective, pockets. If the rest of the world with their nice single payer systems had to pay their share, it'd be a big change. But they don't, and then they look at us without acknowledging, implicitly, they are part of the problem.
Now here's a thought: let's say that evil pharma company comes out with a cure, the only cure, for a disease. They do some accounting, assume this parts ok, and say they need to make $12B on this. Now, the US has 70% of the population for this and Europe has 30%. The company sells the drug in the US for $X, but when they go to Europe they ask each country's heath system to pay a few hundred million, depending on the treatable population they're projected to have. Is a system like that more fair?
Yeah so first part of post is ok but I started to run out of steam. But hopefully I've given a sort-of view of the pharma and biotech landscape. I haven't touched the other side, but here's a couple things.
1. Doctors overtreat because they don't want to be the guy who didn't do a MRI, missed a tumor and then it turns malignant and gets sued 2. Also fee for service (moving off this) 3. Overdiagnosed
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Its been argued, but its fair to say that the US market is the reason pharmaceutical drugs are developed (even if its by a German company).
It's because you can make the most money in a system that you can abuse. You simply can make money as big pharma in the US. A lot more than you could in europe. Martin Shkreli being the best proof as to why pharma companies want a big piece of the US market.
You can exploit the fuck out of peoples health.
Also, nearly all EU countries have a reciprocity-style system where if the FDA approves a drug/device, they submit it to less testing, the US does not, basically another worldwide cost the US bears.
I'd like some form of source for that, because i know for a fact that quite a considerable amount of free "medication" and supplements in the us (approved by FDA) is either restricted in europe, or flat out banned.
edit:
But like cars, I believe we're at the edge of a big discovery. For cars we've got electric and hybrids coming in (though sadly not hover cars). Progress has been slow and is still slow, but we're going to fucking do it.
I do understand what you were trying to say, although that analogy is a bad one. Electric cars existed even before the first combustion engine, the first hybrid engine came out 1901 by Ferdinand Porsche. 
Actually, it might be a good one. Because i do believe as well, that we can improve on existing drugs (the same way we can improve the concept "car"). Get rid of side effects, make them work faster, that kind of stuff. But in the end, all that already existed hundreds of years ago.
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That was a rare gem of thread pwnage. I think we should stick to discussing what healthcare system is best, rather than blaming big pharma for everything that is wrong with it.
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On January 16 2016 11:59 Nyxisto wrote: I guess his point is rather that the US is subsidizing the EU through research but I don't really know why it makes sense from an American perspective to keep doing that at the expense of their own citizens, and I'm not even sure if the US leading position in research is at all connected to the expensive healthcare system.
It is connected, and yes it doesn't make sense, its not 100% of the problem as I address below. The problem is that healthcare innovation worldwide is a diner's dilemma problem: Every country is individually incentivized to reduce its own costs using price controls, but each that does makes the collective international community, as a whole, worse off.
On January 16 2016 12:11 Toadesstern wrote:Show nested quote +On January 16 2016 11:59 Nyxisto wrote: I guess his point is rather that the US is subsidizing the EU through research but I don't really know why it makes sense from an American perspective to keep doing that at the expense of their own citizens, and I'm not even sure if the US leading position in research is at all connected to the expensive healthcare system. he's not arguing that the US research is leading because of the US market, he's arguing that every research, including the european ones are where they are because of the US market.
Yes. I am arguing that, in the extreme. I don't think its 100%, of course, but even if we are 40% of company's per pill profits, that's absurd given Western populations, not to mention the freeloading countries of India and China.
@IGNE You are just absolutely wrong on the lack of development of new drugs. We have a 70%+ effective cure for Hep-C, which is a scourge. The survival rates of cancers are getting ever longer and better. HIV has gone from a 2-3 year death sentence to 10 years at 2000 to 20+ if you are healthy and contract it today. There are dissolving/resorbing stents that will be on the market that are absurdly effective at reducing complications.
And its not just pharma that I am talking about. Its developing new procedures, new devices, new systems, etc.
On January 16 2016 12:50 Nyxisto wrote: If I remember correctly the US has significantly more mri scan's, surgeries, medication prescriptions and so on than any other developed nation often without any advantage in outcome so I'd agree that the for-profit model is creating the wrong incentives here.
Yes. We aren't a perfect system. The massive emphasis on 3rd party payer for even routine procedures drives up those kinds of costs. Our doctors and other high-end professionals have to undergo more training (much of it useless) than in other countries, driving up the required salaries, and the FDA doesn't have reciprocity (which they are actually proposing to fix) which could cut 10% off American long-term costs, basically for free.
On January 16 2016 14:09 m4ini wrote:Show nested quote +Its been argued, but its fair to say that the US market is the reason pharmaceutical drugs are developed (even if its by a German company). It's because you can make the most money in a system that you can abuse. You simply can make money as big pharma in the US. A lot more than you could in europe. Martin Shkreli being the best proof as to why pharma companies want a big piece of the US market. You can exploit the fuck out of peoples health. Show nested quote +Also, nearly all EU countries have a reciprocity-style system where if the FDA approves a drug/device, they submit it to less testing, the US does not, basically another worldwide cost the US bears. I'd like some form of source for that, because i know for a fact that quite a considerable amount of free "medication" and supplements in the us (approved by FDA) is either restricted in europe, or flat out banned. edit: Show nested quote +But like cars, I believe we're at the edge of a big discovery. For cars we've got electric and hybrids coming in (though sadly not hover cars). Progress has been slow and is still slow, but we're going to fucking do it. I do understand what you were trying to say, although that analogy is a bad one. Electric cars existed even before the first combustion engine, the first hybrid engine came out 1901 by Ferdinand Porsche.  Actually, it might be a good one. Because i do believe as well, that we can improve on existing drugs (the same way we can improve the concept "car"). Get rid of side effects, make them work faster, that kind of stuff. But in the end, all that already existed hundreds of years ago.
If you cite Shkreli as an indictment of free markets, you have no idea how our system works. He was granted a monopoly by the FDA on a drug that was previously generic. But sure, that is another reason the American system doesnt work great: the FDA is highly subject to regulatory capture.
Also on subsidies/reciprocity. US Subsidizes EU Reciprocity being proposed by FDA Bill for reciprocity
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The most hated person in the world would be an individual who discovered a one-shot cure for high blood pressure and then priced it based on how much money it would save an individual/their insurance over the course of their life time.
But, if people insist on making healthcare a market (and accepting that this implicitly means rich people deserve to live longer than poor people), that's really the only rational thing for that person to do, so you can't get upset about how they're doing it.
(By the way, there's no HIV vaccines-are you talking about treatment with antiviral agents to prevent transmission ? And none of the Ebola treatments were actually all that useful compared to just treating people with fluids/etc. from the research I did on rotation back then, so it's hard to say that was a success, pretty much just throwing untested things at people and crossing our fingers)
But overall big pharma is not really being all that evil. They're just doing exactly what they should be doing in a market-based healthcare economy, complete with questionable advertising and buying up and gutting small competitors.
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On January 16 2016 14:23 TheTenthDoc wrote: The most hated person in the world would be an individual who discovered a one-shot cure for high blood pressure and then priced it based on how much money it would save an individual/their insurance over the course of their life time.
But, if people insist on making healthcare a market (and accepting that this implicitly means rich people deserve to live longer than poor people), that's really the only rational thing for that person to do, so you can't get upset about how they're doing it.
(By the way, there's no HIV vaccines-are you talking about treatment that prevents transmission with antiviral agents? And none of the Ebola treatments were actually all that useful compared to just treating people with fluids/etc. from the research I did on rotation back then, so it's hard to say that was a success, pretty much just throwing untested things at people and crossing our fingers)
Yes, retrovirals. Obviously if there was a cure I would have said that. There is a cure for Hep-C that is highly effective, but people cry about how its like 90 grand.
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on a different, way funnier topic:
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Which means that it's not "the US bearing another world wide cost". The links clearly say that Europe conducts it's own research into things, which the FDA didn't/doesn't adopt for whatever reasons Including deadly consequences for many people.
There's no one to blame for that but the FDA/your government. Btw, in that first link..
So to recap, although we actually take fewer drugs than people in other countries
That was funny.
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Guess what the market share is on the hep and HIV drugs ticklish and clutz are talking about? Those aren't blockbuster drugs. They don't make Big Pharma money. And my argument here is that there are other ways to fund that research than through companies that are competing for profits. Most of your guys' legitimate points only graze the larger point I was making about the industry. Like if you are going to make arguments about the big stride that Pharma is taking at least connect them back to the point about economic viability.
By the way, this wasn't a blame big pharma for everything. This was a clutz is wrong about healthcare outcomes being dependent on a vibrant US corporate pharma climate.
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On January 16 2016 14:23 TheTenthDoc wrote: The most hated person in the world would be an individual who discovered a one-shot cure for high blood pressure and then priced it based on how much money it would save an individual/their insurance over the course of their life time.
But, if people insist on making healthcare a market (and accepting that this implicitly means rich people deserve to live longer than poor people), that's really the only rational thing for that person to do, so you can't get upset about how they're doing it.
(By the way, there's no HIV vaccines-are you talking about treatment with antiviral agents to prevent transmission ? And none of the Ebola treatments were actually all that useful compared to just treating people with fluids/etc. from the research I did on rotation back then, so it's hard to say that was a success, pretty much just throwing untested things at people and crossing our fingers)
But overall big pharma is not really being all that evil. They're just doing exactly what they should be doing in a market-based healthcare economy, complete with questionable advertising and buying up and gutting small competitors.
Well, he'd have to price it slight under the lifetime cost of the illness 
Yeah you're probably right-- I was thinking along the lines of infection prevention, and now that I think about it was more gels and such that had a 60% chance of preventing transmission in trials. My summer lab (the Vaccine Center @ Yerkes) was looking at some vaccines had a project looking at a potential vaccine, but I don't think it was panning out. I went to Emory and we handled the treatment for that doctor who got Ebola-- the school hyped it up waaaaaaay too much, but there's a bunch of vaccines in development though none are approved even w/ FDA fasttrack.
Still, the fact that we can shit out so many candidates (though a lot don't pan out) is still pretty neat and says a lot about our insane capability for basic research. We used to wander around in the dark for cures. Now, we have a light though oftentimes we don't which direction to go. But we're getting hell of a lot better at it. I'm really excited for Nantworks to get their platform up and running, it should help accelerate info sharing and data crunching by a huge amount.
On January 16 2016 14:55 IgnE wrote: Guess what the market share on the hep and HIV drugs ticklish and clutz are talking about? Those aren't blockbuster drugs. They don't make Big Pharma money. And my argument here is that there are other ways to fund that research than through companies that are competing for profits. Most of your guys' legitimate points only graze the larger point I was making about the industry. Like if you are going to make arguments about the big stride that Pharma is taking at least connect them back to the point about economic viability.
By the way, this wasn't a blame big pharma for everything. This was a clutz is wrong about healthcare outcomes being dependent on a vibrant US corporate pharma climate.
I'm unsure what you're defining blockbuster drug as... if you mean a drug that can see wide distribution in addition to $$$, I'm unsure if any exist because the illnesses we have yet to develop cures need specific therapies. I guess there's Alzheimer's and such, but all I can say is that those are hard to treat. Maybe we'll fix it-- I think we will. But we have to accept that the human body just wasn't designed to last so long and in our current concrete jungles.
Too lazy to pull the number, but Solvadi made like... $8-10 billion last year I think? About half their revenue. I should read Gilead's most recent reports, but the stock tanked and my portfolio hurts. Is it kind of an obscene price? Yes, $1,000 a pill is stupid, I get annoyed that Zyrtec i $1 a pill (thank goodness for Costco generic). But we have to recognize that it's a price that we pay for our healthcare system-- not the US alone, but the world.
Look at it from this angle, which I think makes sense to a degree: ignoring everything else, we pay a big risk premium to pharma because drugs are expensive, risky, long-term investments that no one else can or is willing to take. We can try and decrease costs, hedge risks or increase rewards. And we can't really do that on a national level, we have to do it on a global level like with climate change.
IMO drug pricing should be top down. Look at the market for a drug and calculate the cost to people as a whole as TheTenthDoc mentioned. Put a prize out based on that and offer grants and research for working on research with amounts for milestones and successes with the caveat that they have to price at a certain level if they opt in. Make the dollars real big. Let pharma pick their bets.
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