The Zerg unit responses all sound like bugs and don't have the same roaring, growling, and hissing. They've become more a bug swarm than the more Aliens inspired designs of the originals. Protoss are great but the zealot needs a more intimidating running animation. The way the original haunched his shoulders in BW was a lot more threatening. Lastly, the Terran are a lot more round and lack the "dirty metal" feel of the original Terrans. The siege tank is probably the best visual improvement of any terran units, as everything else is a bit too round and bubbly. Hell, watch the marauder's running animation up close and try not to laugh.
Listen to a BW game sometimes you can really feel the degradation in sound quality from BW to SC2. in BW things have a lot more impact and a LOT more bass. Listen to BW siege tanks fire, marines machine guns blazing, or goliaths firing their guns. All the attack sounds in BW have a lot more impact and are much deeper sounds. SC2 seems to lack even the illusion of bass in its sounds.
I don't know if I'd describe SC2 as more "cartoony" but I'd definitely say it's several steps down in all departments except for graphics and a few voices like the new SCV and Marauder.