I was testing soulrend of reaping mines yesterday and it seems like it'd be pretty good clear if you could deal with the mana costs. The base numbers are pretty high, so single target would probably also be decent.
Mana's the big question mark. With them nerfing mana reduction into efficiency, no inspiration for chaos, and lightning costs getting turbonerfed, I'm not sure anything hit based is viable for those. If you don't need to chain cast maybe you can still get away with it.
The cold keystone also just seems busted. I'm really expecting it to get nerfed pre-launch. It shouldn't be hard to get 20-30 chill on any endgame build, and that's just a crazy amount of damage for one point. I've been thinking phys (with the 10% base crit) cold converting is the way to go, but I'm just not sold on any of the spells.
I'm interested in playing Assassin, but I'd prefer to have an attack for Deathmark, which really limits your options to some kind of CWC/COC/Spellslinger build. I just can't seem to make anything stick for starting out.