Official 'what is Dota anymore' discussion - Page 586

Seriously though, it's EXTREMELY important to keep in mind what this graph is representing. This is basically "risk of overdose" chart. Ratio between Toxic dose vs. average intake. So something like alcohol, you only need to consume 2-4x as much as a "normal" dose to be at risk of serious health concerns. Meanwhile something like 15x meth consumption compared to normal is required for a toxic dose, while it is virtually impossible to overdose on Marijuana. It is interesting to note how low the relative toxic doses of two of the most common legal substances are (tobacco and alcohol). I didn't even realize Nicotine Poisoning was a thing.
This in no way takes into account any sort of other consequences of drug use. Side effects, addiction rates, injury due to consumption (drunk driving) and countless other factors are being ignored, as that is not what this test is about. Meth may be only a moderate risk of overdose, but there are also a large number of other health issues, long and short term, that must also be considered.
TLDR: This chart is all about how much it takes to overdose. You may not overdose on meth, but it can still fuck you up long and short term.

The MOE is a tool used by risk assessors to consider possible safety concerns arising from the presence in food and feed of substances which are both genotoxic (that is, which may damage DNA, the genetic material of cells) and carcinogenic. The MOE is a ratio of two factors which assesses for a given population the dose at which a small but measurable adverse effect is first observed and the level of exposure to the substance considered.

Risk assessors at EFSA use the MOE approach to consider possible safety concerns arising from the presence in food and feed of substances which are both genotoxic and carcinogenic. The presence of substances which are both genotoxic and carcinogenic in food and feed, while not desirable, could result from environmental pollution or manufacturing processes.

The MOE is not used to assess the safety of regulated substances deliberately added to the food chain (for instance food and feed additives or food contact materials). However, EFSA’s Scientific Committee advised in a statement published in March 2012 that it could be useful in assessing the safety of any genotoxic and carcinogenic impurities present in such substances at very low levels. Use of the MOE can in this way help support risk managers in defining possible actions required to keep exposure to such substances as low as possible.

EFSA’s Scientific Committee published a first opinion in October 2005 recommending the use of the MOE approach for the safety assessment of contaminants that are both genotoxic and carcinogenic.